Evidence map›Paper›PMID 31651246›Full record

Trial reportBMC anesthesiology2019

Comparative study between intrathecal dexmedetomidine and intrathecal magnesium sulfate for the prevention of post-spinal anaesthesia shivering in uroscopic surgery; (RCT).

Heba Omar, Wessam Adel Aboella, Mohammed Mahmoud Hassan, Amany Hassan, Passaint Hassan, Ahmed Elshall, Dalia Khaled, Maha Mostafa, Pierre Zarif Tawadros, Mona Hossam Eldin and 2 more

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. 5-HTBMJ open · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Heba OmarAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Wessam Adel AboellaEl Sahel Teaching Hospital, Cairo, Egypt.
Mohammed Mahmoud HassanAnesthesia Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Amany HassanAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Passaint HassanAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed ElshallAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Dalia KhaledAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Maha MostafaAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Pierre Zarif TawadrosAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mona Hossam EldinAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mai WedadAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Bassant Mohamed AbdelhamidAnesthesia Department, Faculty of Medicine, Cairo University, Cairo, Egypt. bassantmohamed197@yahoo.com.ORCID 0000-0001-8938-4175
Cairo University · EGShebin Teaching Hospital · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypothermia and shivering are common complications after spinal anaesthesia, especially after uroscopic procedures in which large amounts of cold intraluminal irrigation fluids are used. Magnesium sulfate and dexmedetomidine are the most effective adjuvants with the least side effects. The aim of this study was to compare the effects of intrathecal dexmedetomidine versus intrathecal magnesium sulfate on the prevention of post-spinal anaesthesia shivering.

methodsThis prospective randomized, double-blinded controlled study included 105 patients who were scheduled for uroscopic surgery at the Kasr El-Aini Hospital. The patients were randomly allocated into three groups. Group C (n = 35) received 2.5 ml of hyperbaric bupivacaine 0.5% (12.5 mg) + 0.5 ml of normal saline, Group M (n = 35) received 2.5 ml of hyperbaric bupivacaine 0.5% (12.5 mg) + 25 mg of magnesium sulfate in 0.5 ml saline, and Group D (n = 35) received 2.5 ml of hyperbaric bupivacaine 0.5% (12.5 mg) + 5 μg of dexmedetomidine in 0.5 ml saline. The primary outcomes were the incidence and intensity of shivering. The secondary outcomes were the incidence of hypothermia, sedation, the use of meperidine to control shivering and complications.

resultsGroup C had significantly higher proportions of patients who developed shivering (21), developed grade IV shivering (20) and required meperidine (21) to treat shivering than group M (8,5,5) and group D (5,3,6), which were comparable to each other. The time between block administration and meperidine administration was similar among the three groups. Hypothermia did not occur in any of the patients. The three groups were comparable regarding the occurrence of nausea, vomiting, bradycardia and hypotension. All the patients in group C, 32 patients in group M and 33 patients in group D had a sedation score of 2. Three patients in group M and 2 patients in group D had a sedation score of 3.

conclusionsIntrathecal injections of both dexmedetomidine and magnesium sulfate were effective in reducing the incidence of post-spinal anaesthesia shivering. Therefore, we encourage the use of magnesium sulfate, as it is more physiologically available, more readily available in most operating theatres and much less expensive than dexmedetomidine.

trial registrationClinical trial registration ID: Pan African Clinical Trial Registry (PACTR) Trial Number PACTR201801003001727 ; January 2018, "retrospectively registered".

Indexed as

Adrenergic alpha-2 Receptor AgonistsAdultAnesthesia, SpinalAnestheticsAnesthetics, LocalBupivacaineDexmedetomidineDouble-Blind MethodFemaleHumansHypothermiaInjections, SpinalMagnesium SulfateMaleMeperidineMiddle AgedAdrenergic alpha-2 Receptor AgonistsAnestheticsAnesthetics, LocalBupivacaineDexmedetomidineMagnesium SulfateMeperidineDexmedetomidineMagnesiumShiveringSpinal

Identifiers

PMID31651246
PMCPMC6814123
OpenAlexW2982126560

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.