Evidence map›Paper›PMID 31650957›Full record

ArticleeLife2019

Phage integration alters the respiratory strategy of its host.

Jeffrey N Carey, Erin L Mettert, Daniel R Fishman-Engel, Manuela Roggiani, Patricia J Kiley, Mark Goulian

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Gut virome dynamics: from commensal to critical player in health and disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Global phylogenomic analysis ofMicrobial genomics · 2025
    Article
  9. Article
  10. Article
  11. Genotypic and phenotypic analysis ofFrontiers in microbiology · 2024
    Article
  12. Review
  13. A TemperateViruses · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Distribution of Prophages in theMicroorganisms · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jeffrey N CareyGraduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-5105-0265
Erin L MettertDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, United States.
Daniel R Fishman-EngelDepartment of Biology, University of Pennsylvania, Philadelphia, United States.
Manuela RoggianiDepartment of Biology, University of Pennsylvania, Philadelphia, United States.
Patricia J KileyDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, United States.
Mark GoulianGraduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-0076-023X
University of Pennsylvania · USUniversity of Wisconsin–Madison · US

Funding

Regulation of Bacterial Two-Component Signaling by Small Membrane ProteinsR01GM080279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2007 to 2020
$3.7M
VMD-PhD Training in Infectious Disease-Related ResearchT32AI070077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2008 to 2026
$3.5M
Bacterial anaerobic iron homeostasisR01GM115894 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KILEY, PATRICIA J · 2015 to 2018
$1.2M
NIAID NIH HHS T32 AI070077NIGMS NIH HHS R01 GM080279NIGMS NIH HHS R01 GM115894NIH HHS R01-GM080279NIH HHS R01-GM115894
6 · The paper itself

Abstract

Temperate bacteriophages are viruses that can incorporate their genomes into their bacterial hosts, existing there as prophages that refrain from killing the host cell until induced. Prophages are largely quiescent, but they can alter host phenotype through factors encoded in their genomes (often virulence factors) or by disrupting host genes as a result of integration. Here we describe another mechanism by which a prophage can modulate host phenotype. We show that a temperate phage that integrates in

Indexed as

Energy MetabolismGene Expression Regulation, BacterialVirus IntegrationAnaerobiosisColiphagesEscherichia coliProphagesSignal Transductionbacteriophagebet hedgingchromosomesE. coligene expressioninfectious diseasemicrobiologytrimethylamine N-oxidetwo-component signaling

Identifiers

PMID31650957
PMCPMC6814406
OpenAlexW2981354744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.