IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis

Gökhan Kuran, Hüseyin Aslan, Süheyl Haytoğlu, Özge Özalp Yüreğir, Sevcan Tuğ Bozdoğan

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In one paragraph

Article in Turkish journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.9field-weighted citation impact, top 26% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

Polymorphisms in HumanGenes · 2022
Article

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gökhan KuranAdana City Training and Research Hospital, ENT Department, Adana, TurkeyORCID 0000-0002-0709-1887

Hüseyin AslanEskisehir Osmangazi University Medical Faculty, Department of Medical Genetics, Eskisehir, TurkeyORCID 0000-0003-3542-4340

Süheyl HaytoğluAdana City Training and Research Hospital, ENT Department, Adana, TurkeyORCID 0000-0002-4409-9781

Özge Özalp YüreğirAdana City Training and Research Hospital, Department of Medical Genetics, Adana, TurkeyORCID 0000-0002-7343-3064

Sevcan Tuğ BozdoğanMersin University Medical Faculty, Department of Medical Genetics, Mersin, TurkeyORCID 0000-0003-3853-8212

Eskişehir Osmangazi University · TRMersin Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmental factors. In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease. Materials and methods: A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, were analyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction. Results: IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036, respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between the patient and control groups (P = 0.235). Conclusions: Our study indicates that the RN2 allele of IL-1RN and the RP1 allele of IL-4 might be risk factors for developing sinonasal polyposis.

Indexed as

AdolescentAdultAgedAged, 80 and overAllelesCase-Control StudiesChronic DiseaseFemaleGenetic Predisposition to DiseaseHumansInterleukin 1 Receptor Antagonist ProteinInterleukin-2Interleukin-4MaleMiddle AgedMinisatellite RepeatsIL1RN protein, humanIL2 protein, humanIL4 protein, humanInterleukin 1 Receptor Antagonist ProteinInterleukin-2Interleukin-4gene polymorphismIL-1RN VNTRIL-2(-330)IL-4 VNTRNasal polyposis

Identifiers

PMID31650822

DOI10.3906/sag-1710-186

PMCPMC7018318

OpenAlexW2981686375

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.