ArticleAngewandte Chemie (International ed. in English)2020
Site-Selective Alkoxylation of Benzylic C-H Bonds by Photoredox Catalysis.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Formal Hydride Abstraction: A Unified Photoredox Platform for Nucleophilic C(sp3)-H Functionalization.Accounts of chemical research · 2026Article
- Deprotonative Single-Electron Oxidation as a General and Controllably Selective Platform for Benzylic C-H Functionalization.Journal of the American Chemical Society · 2026Article
- Copper-Catalyzed Three-Component Selective 1,4-Amino Oxygenation of 1,3-Dienes.Angewandte Chemie (International ed. in English) · 2026Article
- Harnessing Photochemistry in Natural Product Synthesis: From Strategy to Applications.Journal of natural products · 2025Review
- Asymmetric Synthesis of Cycloartobiloxanthone.Organic letters · 2025Article
- Three-Component Catalytic Amino Etherification of Alkenes: Enabled by Silyl Ether-Promoted C-O Coupling.ACS catalysis · 2025Article
- Sustainable Approaches for the Protection and Deprotection of Functional Groups.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- A General Strategy for C(spAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Facile Access to Hindered Ethers via Photoinduced O-H Bond Insertions.ACS central science · 2025Article
- C(spACS catalysis · 2025Article
- An Organometallic Umpolung Approach for Iron-Mediated Propargylic C-H Etherification.Angewandte Chemie (International ed. in English) · 2024Article
- Direct Benzylic C-H Etherification Enabled by Base-Promoted Halogen Transfer.Angewandte Chemie (International ed. in English) · 2024Article
- Palladium-catalyzed cross-coupling of alcohols with olefins by positional tuning of a counteranion.Science (New York, N.Y.) · 2024Article
- Total Synthesis of Dragocins A-C through Electrochemical Cyclization.Angewandte Chemie (International ed. in English) · 2024Article
- Mechanistic insights into radical formation and functionalization in copper/Chemical science · 2024Article
- Cu(II) salts as terminal oxidants in visible-light photochemical oxidation reactions.Organic & biomolecular chemistry · 2023Review
- Polar Heterobenzylic C(spJournal of the American Chemical Society · 2023Article
- Tuning Benzylic C-H Functionalization of (Thio)xanthenes with Electrochemistry.Molecules (Basel, Switzerland) · 2023Article
- Light-induced homolysis of copper(ii)-complexes - a perspective for photocatalysis.Chemical science · 2023Review
- Synthesis of triarylmethanes by silyl radical-mediated cross-coupling of aryl fluorides and arylmethanes.Chemical science · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Methods that enable the direct C-H alkoxylation of complex organic molecules are significantly underdeveloped, particularly in comparison to analogous strategies for C-N and C-C bond formation. In particular, almost all methods for the incorporation of alcohols by C-H oxidation require the use of the alcohol component as a solvent or co-solvent. This condition limits the practical scope of these reactions to simple, inexpensive alcohols. Reported here is a photocatalytic protocol for the functionalization of benzylic C-H bonds with a wide range of oxygen nucleophiles. This strategy merges the photoredox activation of arenes with copper(II)-mediated oxidation of the resulting benzylic radicals, which enables the introduction of benzylic C-O bonds with high site selectivity, chemoselectivity, and functional-group tolerance using only two equivalents of the alcohol coupling partner. This method enables the late-stage introduction of complex alkoxy groups into bioactive molecules, providing a practical new tool with potential applications in synthesis and medicinal chemistry.
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