Evidence map›Paper›PMID 31650641›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019

On the Mechanism of the Asymmetric Aldol Addition of Chiral N-Amino Cyclic Carbamate Hydrazones: Evidence of Non-Curtin-Hammett Behavior.

Md Nasir Uddin, John D Knight, Ettore J Rastelli, Chirine Soubra-Ghaoui, Thomas A Albright, Chia-Hua Wu, Judy I Wu, Don M Coltart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Md Nasir UddinDepartment of Chemistry, University of Houston, Houston, Texas, 77204, USA.
John D KnightDepartment of Chemistry, University of Houston, Houston, Texas, 77204, USA.
Ettore J RastelliDepartment of Chemistry, University of Houston, Houston, Texas, 77204, USA.
Chirine Soubra-GhaouiDepartment of Chemistry and Physics, University of St. Thomas, Houston, Texas, 77006, USA.
Thomas A AlbrightDepartment of Chemistry, University of Houston, Houston, Texas, 77204, USA.
Chia-Hua WuDepartment of Chemistry, University of Houston, Houston, Texas, 77204, USA.
Judy I WuDepartment of Chemistry, University of Houston, Houston, Texas, 77204, USA.
Don M ColtartDepartment of Chemistry, University of Houston, Houston, Texas, 77204, USA.ORCID http://orcid.org/0000-0003-2675-3070

Funding

Unlocking Biologically-Relevant Opportunities Through Applications of Excited-State Aromaticity and AntiaromaticityR35GM133548 · NIGMS · UNIVERSITY OF HOUSTON · PI WU, JUDY I-CHIA · 2019 to 2025
$3.8M
National Science Foundation MRI-1531814National Science Foundation NSF 1300652NIGMS NIH HHS R35 GM133548Welch Foundation E-1806
6 · The paper itself

Abstract

he mechanistic details of the aldol addition of N-amino cyclic carbamate (ACC) hydrazones is provided herein from both an experimental and computational perspective. When the transformation is carried out at room temperature the anti-aldol product is formed exclusively. Under these conditions the anti- and syn-aldolate intermediates are in equilibrium and the transformation is under thermodynamic control. The anti-aldolate that leads to the anti-aldol product was calculated to be 3.7 kcal mol

Indexed as

aldolCurtin-Hammettdensity functional calculationskineticsreaction mechanisms

Identifiers

PMID31650641
PMCPMC7182504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.