Evidence map›Paper›PMID 31650629›Full record

ArticleJournal of veterinary internal medicine2019

Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b

Jared A Jaffey, N Scott Reading, Urs Giger, Osheiza Abdulmalik, Ruben M Buckley, Sophie Johnstone, Leslie A Lyons, 99 Lives Cat Genome Consortium

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Jared A JaffeyDepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine, Midwestern University, Glendale, Arizona.ORCID https://orcid.org/0000-0002-0270-4728
N Scott ReadingInstitute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah.
Urs GigerSection of Medical Genetics (PennGen), School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Osheiza AbdulmalikDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Ruben M BuckleyDepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri.
Sophie JohnstoneSouth Coastal Animal Health, Weymouth, Massachusetts.
Leslie A LyonsDepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri.
99 Lives Cat Genome Consortium
Missouri College · USChildren's Hospital of Philadelphia · USMidwestern University · USSouth Shore Hospital · USUniversity of Pennsylvania · USUniversity of Utah · US

Funding

Elanco Animal Health IncNIH OD010939NIH R01MD009124
6 · The paper itself

Abstract

Two non-pedigreed male castrated cats had persistent cyanosis over a 3-year observation period. Clinical cardiopulmonary evaluations did not reveal abnormalities, but the blood remained dark after exposure to air. Erythrocytic methemoglobin concentrations were high (~40% of hemoglobin) and cytochrome b

Indexed as

Genetic Predisposition to DiseaseAmino Acid SequenceAnimalsCat DiseasesCatsCytochromes b5Fatal OutcomeMaleMethemoglobinemiaMutationCytochromes b5cyanosisCYB5R3cytochrome b5 reductasemethylene bluewhole-genome sequencing

Identifiers

PMID31650629
PMCPMC6872605
OpenAlexW2981612397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.