Evidence map›Paper›PMID 31650487›Full record

Trial reportChinese journal of integrative medicine2019

Phonopheresis Associated with Nanoparticle Gel from Phyllanthus amarus Relieves Pain by Reducing Oxidative Stress and Proinflammatory Markers in Adults with Knee Osteoarthritis.

Pinkaew Decha, Kiattisin Kanokwan, Tocharus Jiraporn, Jumnongprakhon Pichaya, Awoot Pisittawoot

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Chinese journal of integrative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. An insight into the potent medicinal plantThe Nucleus : an international journal of cytology and allied topics · 2022
    Review
  8. Healthcare and Scientific Treatment of Knee Osteoarthritis.Journal of healthcare engineering · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pinkaew DechaDepartment of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand. Decha303@gmail.com.
Kiattisin KanokwanDepartment of Pharmaceutical Sciences. Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand.
Tocharus JirapornDepartment of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Jumnongprakhon PichayaDepartment of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
Awoot PisittawootDepartment of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the changes in serum levels of inflammatory biomarkers and antioxidant levels among the knee osteoarthritis (OA) patients after treatment with Phyllanthus amarus (PP) by nanoparticle gel phonophoresis.

methodsThis study was a randomized, double-blind, placebo-control, parallel-group, clinical trial involving 30 subjects with mild-to-moderate degree of knee OA. The patients were allocated to two groups using a computer-generated random numbers, and received conventional ultrasound therapy (control group, 15 cases) and PP (treatment group, 15 cases) once daily for 10 sessions. The pain was evaluated by visual analogue scale (VAS). Serum levels of tumor necrosis factor-α (TNF-α) were determined by enzyme-linked immunosorbnent assay (ELISA). Nitric oxide (NO) was determined by modified Griess reagent. The antioxidant effects, including superoxide dismutase (SOD) and total antioxidant capacity (TAC), were also measured by ELISA assay.

resultsThe VAS score was significantly decreased in the treatment group compared with the control group after treatment (P<0.01). The serum concentrations of TNF-α and NO were significantly reduced in the treatment group compared with the control group (P<0.01) after treatment. However, the serum concentrations of SOD and TAC in the treatment group were significantly higher after treatment compared with the control group (P<0.01).

conclusionPP could alleviate knee pain and significantly reduce systemic anti-inflammatory effects in knee OA patients.

Indexed as

Oxidative StressUltrasonicsAdultAgedAntioxidantsBiomarkersGelsHumansInflammation MediatorsMiddle AgedNanoparticlesNitratesNitritesOsteoarthritis, KneePainPain MeasurementAntioxidantsBiomarkersGelsInflammation MediatorsNitratesNitritesSuperoxide DismutaseTumor Necrosis Factor-alphaantioxidantsosteoarthritisphonopheresis associated with nanoparticle gel from Phyllanthus amarusproinflammatory cytokinestotal antioxidant capacitytumor necrosis factor-α

Identifiers

PMID31650487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.