ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
White matter alterations in early Parkinson's disease: role of motor symptom lateralization.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- The relationship between obstructive sleep apnea and Parkinson's disease: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- Assessing White Matter Pathology in Early-Stage Parkinson Disease Using Diffusion MRI: A Systematic Review.Frontiers in neurology · 2020Pooled it
- White Matter Abnormalities in Patients With Parkinson's Disease: A Meta-Analysis of Diffusion Tensor Imaging Using Tract-Based Spatial Statistics.Frontiers in aging neuroscience · 2020Pooled it
- Diffusion-tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Diffusion tensor metrics, motor and non-motor symptoms in de novo Parkinson's disease.Neuroradiology · 2024Article
- Study of the relationship between onset lateralization and hemispheric white matter asymmetry in Parkinson's disease.Journal of neurology · 2023Article
- Brain MRI Biomarkers in Isolated Rapid Eye Movement Sleep Behavior Disorder: Where Are We? A Systematic Review.Brain sciences · 2023Review
- Review
- Crossed functional specialization between the basal ganglia and cerebellum during vocal emotion decoding: Insights from stroke and Parkinson's disease.Cognitive, affective & behavioral neuroscience · 2022Article
- Association between Severity of Freezing of Gait and Turning Characteristics in People with Parkinson's Disease.International journal of environmental research and public health · 2022Article
- Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease.Human brain mapping · 2021Article
- Aberrant Changes in Cortical Complexity in Right-Onset Versus Left-Onset Parkinson's Disease in Early-Stage.Frontiers in aging neuroscience · 2021Article
- The Association Between Clinical Characteristics and Motor Symptom Laterality in Patients With Parkinson's Disease.Frontiers in neurology · 2021Article
- Motor Symptom Lateralization Influences Cortico-Striatal Functional Connectivity in Parkinson's Disease.Frontiers in neurology · 2021Article
- Structural remodeling secondary to functional remodeling in advanced-stage peripheral facial neuritis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- An Integrative Nomogram for Identifying Early-Stage Parkinson's Disease Using Non-motor Symptoms and White Matter-Based Radiomics Biomarkers From Whole-Brain MRI.Frontiers in aging neuroscience · 2020Article
- The Relationship between Side of Onset and Cerebral Regional Homogeneity in Parkinson's Disease: A Resting-State fMRI Study.Parkinson's disease · 2020Article
- Parietal Perfusion Alterations in Parkinson's Disease Patients Without Dementia.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionParkinson's disease (PD) is a motor disorder that initially presents with unilateral symptoms. Widespread white matter (WM) alterations have been reported since the early stages of the disease. The aim of this study was to investigate WM alterations in right-dominant and left-dominant symptom PD patients (RPD and LPD, respectively) with respect to healthy controls (HC) by diffusion-weighted magnetic resonance imaging (MRI).
methodsThirty-eight subjects participated in this study: 12 RPD (median H&Y [IQR] = 1.5 [1.1-2], median UPDRS III [IQR] = 23 [7.8-25]), 9 LPD (median H&Y [IQR] = 1.5 [1-2.5], median UPDRS III [IQR] = 17 [12-22]), and 17 HC. All the participants were scanned on a 1.5-T MRI scanner. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were computed for all the subjects. Tract-based spatial statistics (TBSS) was performed for each diffusion parameter, to test WM differences between RPD, LPD, and HC (ANCOVA design). Family-wise error (FWE) correction was performed and p values lower than 0.05 were considered significant.
resultsNo significant FA and RD differences were observed between RPD, LPD, and HC. Significantly increased MD and AD were observed in RPD with respect to HC within widespread WM regions, bilaterally. Conversely, no significant WM alterations were detected in LPD.
conclusionWM integrity was found to be significantly altered in RPD but not in LPD, suggesting that LPD profile may be associated to more favorable prognosis. Since clinical laterality onset may affect the extent of WM integrity changes, it should be taken into account in neuroimaging studies investigating PD.
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