Evidence map›Paper›PMID 31650437›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020

Sural nerve biopsy in peripheral neuropathies: 30-year experience from a single center.

Marco Luigetti, Andrea Di Paolantonio, Giulia Bisogni, Angela Romano, Amelia Conte, Francesco Barbato, Alessandra Del Grande, Francesca Madia, Paolo Maria Rossini, Liverana Lauretti and 1 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Marco LuigettiUOC Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A Gemelli 8, 00168, Rome, Italy. mluigetti@gmail.com.ORCID http://orcid.org/0000-0001-7539-505X
Andrea Di PaolantonioUniversità Cattolica del Sacro Cuore, Rome, Italy.
Giulia BisogniCentro Clinico NEMO adulti - Roma, Rome, Italy.
Angela RomanoUniversità Cattolica del Sacro Cuore, Rome, Italy.
Amelia ConteCentro Clinico NEMO adulti - Roma, Rome, Italy.
Francesco BarbatoUniversità Cattolica del Sacro Cuore, Rome, Italy.
Alessandra Del GrandeUOC Neurologia, Ospedale Sant'Eugenio, Roma, Italy.
Francesca MadiaUniversità Cattolica del Sacro Cuore, Rome, Italy.
Paolo Maria RossiniUOC Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A Gemelli 8, 00168, Rome, Italy.
Liverana LaurettiUniversità Cattolica del Sacro Cuore, Rome, Italy.
Mario SabatelliUniversità Cattolica del Sacro Cuore, Rome, Italy.
Università Cattolica del Sacro Cuore · ITCentro Clinico Nemo · ITSt. Eugenio Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNerve biopsy has been widely used to investigate patients with peripheral neuropathy, and in many centers, it is still a useful diagnostic tool in this setting. In this study, we reviewed the histopathological spectrum of the nerve biopsies performed in our center in a 30-year period and we analyzed their relevance in the clinical setting. MATERIALS AND

methodsRetrospective analysis of the retrieved data was done for cases of nerve biopsies performed in our institute between 1988 and 2018. Surgical technique and histopathological analysis were done accordingly to standard protocol.

resultsComplete clinical and pathological data were available only for 717 cases. The procedure was generally safe, with only 0.3% superimposed infection. Main pathological results were "unspecific" axonal polyneuropathy (49.8%), vasculitis neuropathy (9.3%), acquired demyelinating neuropathy (8.9%), and Charcot-Marie-Tooth (8.2%). Considering clinical-neurophysiological suspicion of vasculitis, nerve biopsy confirmed the diagnosis in 60.9% of cases. DISCUSSION: In conclusion, for inherited neuropathies, we do not recommend this invasive procedure, but we strongly suggest a genetic test. Conversely, in vasculitic neuropathies or in dysimmune neuropathies not clearly confirmed by neurophysiological examination, nerve biopsy continues to represent a useful and irreplaceable tool.

Indexed as

AdolescentAdultAgedAged, 80 and overBiopsyCharcot-Marie-Tooth DiseaseChildChild, PreschoolFemaleHumansMaleMiddle AgedPolyneuropathiesPolyradiculoneuropathyRetrospective StudiesSural NerveAmyloidCIDPCMTIgM-related neuropathyNerve biopsyNeuropathyVasculitis

Identifiers

PMID31650437
OpenAlexW2981718017

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.