Evidence map›Paper›PMID 31650404›Full record

ArticleObesity surgery2020

Genetic Obesity and Bariatric Surgery Outcome in 1014 Patients with Morbid Obesity.

M I Cooiman, L Kleinendorst, E O Aarts, I M C Janssen, H K Ploos van Amstel, A I Blakemore, E J Hazebroek, H J Meijers-Heijboer, B van der Zwaag, F J Berends and 1 more

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Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Management of Childhood Obesity.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Observational
  11. Review
  12. Precision Medicine in Bariatric Procedures.Gastrointestinal endoscopy clinics of North America · 2024
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. A comprehensive review of genetic causes of obesity.World journal of pediatrics : WJP · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

M I CooimanDepartment of Bariatric Surgery, Rijnstate Hospital Arnhem/Vitalys, Wagnerlaan 55, 6815 AD, Arnhem, the Netherlands. mcooiman@rijnstate.nl.ORCID 0000-0002-4707-0714
L KleinendorstDepartment of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
E O AartsDepartment of Bariatric Surgery, Rijnstate Hospital Arnhem/Vitalys, Wagnerlaan 55, 6815 AD, Arnhem, the Netherlands.
I M C JanssenDepartment of Bariatric Surgery, Rijnstate Hospital Arnhem/Vitalys, Wagnerlaan 55, 6815 AD, Arnhem, the Netherlands.
H K Ploos van AmstelDepartment of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
A I BlakemoreDepartment of Life Sciences, Brunel University London, London, UK.
E J HazebroekDepartment of Bariatric Surgery, Rijnstate Hospital Arnhem/Vitalys, Wagnerlaan 55, 6815 AD, Arnhem, the Netherlands.
H J Meijers-HeijboerDepartment of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
B van der ZwaagDepartment of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
F J BerendsDepartment of Bariatric Surgery, Rijnstate Hospital Arnhem/Vitalys, Wagnerlaan 55, 6815 AD, Arnhem, the Netherlands.
M M van HaelstDepartment of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Rijnstate Hospital · NLAmsterdam University Medical Centers · NLUniversity Medical Center Utrecht · NLImperial College London · GBNederlandse Obesitas Kliniek · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMutations in the leptin-melanocortin pathway genes are known to cause monogenic obesity. The prevalence of these gene mutations and their effect on weight loss response after bariatric surgery are still largely unknown.

objectiveTo determine the prevalence of genetic obesity in a large bariatric cohort and evaluate their response to bariatric surgery.

methodsMutation analysis of 52 obesity-associated genes. Patient inclusion criteria were a BMI > 50 kg/m

resultsA total of 1014 patients were included, of whom 30 (3%) were diagnosed with genetic obesity, caused by pathogenic heterozygous mutations in either MC4R, POMC, PCSK1, SIM1, or PTEN. The percentage total body weight loss (%TBWL) after Roux-en-Y gastric bypass (RYGB) surgery was not significantly different for patients with a mutation in MC4R, POMC, and PCSK1 compared with patients lacking a molecular diagnosis. Of the confirmed genetic obesity cases, only patients with MC4R mutations receiving a sleeve gastrectomy (SG) showed significantly lower %TBWL compared with patients lacking a molecular diagnosis, during 2 years of follow-up.

conclusionsIn this cohort of morbid obese bariatric patients, an estimated prevalence of monogenic obesity of 3% is reported. Among these patients, the clinical effects of heterozygous mutations in POMC and PCSK1 do not interfere with the effectiveness of most commonly performed bariatric procedures within the first 2 years of follow-up. Patients with MC4R mutations achieved superior weight loss after primary RYGB compared with SG.

Indexed as

Bariatric SurgeryAdolescentAdultAgedFemaleGastrectomyGastric BypassHumansMaleMiddle AgedMutationObesity, MorbidPrognosisReoperationRetrospective StudiesTreatment OutcomeBariatric surgeryEarly onset obesityGastric bypassObesityObesity geneticsRevisional surgerySleeve gastrectomy

Identifiers

PMID31650404
OpenAlexW2982089384

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.