Evidence map›Paper›PMID 31650393›Full record

Observational studyEndocrine2020

Hypomagnesaemia and its determinants in a contemporary primary care cohort of persons with type 2 diabetes.

Femke Waanders, Robin P F Dullaart, Michel J Vos, Steven H Hendriks, Harry van Goor, Henk J G Bilo, Peter R van Dijk

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Femke WaandersDepartment of Nephrology, Isala, Zwolle, The Netherlands.
Robin P F DullaartDepartment of Endocrinology, University Medical Center, University of Groningen, Groningen, The Netherlands.
Michel J VosDepartment of Clinical Chemistry, Isala, Zwolle, The Netherlands.
Steven H HendriksDepartment of General practice, University of Leiden, Leiden, The Netherlands.
Harry van GoorDepartment of Pathology and Medical Biology, University Medical Center, University of Groningen, Groningen, The Netherlands.
Henk J G BiloDepartment of Internal Medicine, University Medical Center, University of Groningen, Groningen, The Netherlands.
Peter R van DijkDepartment of Endocrinology, University Medical Center, University of Groningen, Groningen, The Netherlands. p.r.van.dijk@umcg.nl.ORCID 0000-0002-9702-6551
University Medical Center Groningen · NLIsala · NLLeiden University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAmong persons with type 2 diabetes mellitus (T2DM) hypomagnesaemia has been reported in 14-48% of patients. This may be of significance given the emerging associations of hypomagnesaemia with glucometabolic disturbances and possibly even complications. We assessed the prevalence of hypomagnesaemia and its determinants, in a well-defined cohort of persons with T2DM treated in primary care.

methodsObservational cohort study among persons with T2DM treated in primary care in the Northeast of the Netherlands. Magnesium was measured using a colorimetric endpoint assay (Roche). Hypomagnesaemia was defined as a serum magnesium level <0.70 mmol/L. Pearson correlations were performed to correlate variables with serum magnesium. Next, a stepwise backward regression model was made.

resultsData of 929 persons (55% male) with a mean age of 65 (± 10) years, diabetes duration 6.5 [3.0-10.1] years, and HbA1c concentration 6.7 (± 0.7)% (50 (± 9) mmol/mol) were analysed. Serum magnesium was 0.79 (± 0.08) mmol/L. The percentage of persons with magnesium deficiency was 9.6%. Age, diabetes duration, BMI, HbA1c, use of metformin, sulfonylurea derivatives, and DPP4 inhibitors were negatively associated with magnesium concentrations. In contrast, LDL cholesterol and serum creatinine were positively associated serum magnesium.

conclusionsHypomagnesaemia was present in 9.6% of T2DM patients treated in primary care. This percentage is remarkably lower than reported previously, possibly due to the unselected nature of our population. Concerning T2DM-related factors, only BMI, HbA1c and the use of metformin, sulfonylurea derivatives and DPP4 inhibitors correlated negatively with magnesium concentrations.

Indexed as

Diabetes Mellitus, Type 2AgedCohort StudiesFemaleHumansMagnesiumMaleMiddle AgedNetherlandsPrimary Health CareMagnesiumHypomagnesaemiaMagnesiumPrevalenceType 2 diabetes

Identifiers

PMID31650393
PMCPMC6968975
OpenAlexW2981467081

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.