ArticleEuropean radiology experimental2019
An isolated beating pig heart platform for a comprehensive evaluation of intracardiac blood flow with 4D flow MRI: a feasibility study.
Article in European radiology experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- 4D-Flow Cardiac Magnetic Resonance Imaging: An 8-Year Clinical Practice Review.Reviews in cardiovascular medicine · 2026Review
- Real-time magnetic resonance-guided radiofrequency ablation and lesion evaluation in an magnetic resonance-compatible isolated beating pig heart platform.Heart rhythm O2 · 2025Article
- Design and Analysis of a Polymeric Left Ventricular Simulator via Computational Modelling.Biomimetics (Basel, Switzerland) · 2024Article
- Robotic right ventricle is a biohybrid platform that simulates right ventricular function in (patho)physiological conditions and intervention.Nature cardiovascular research · 2023Article
- Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance.Current transplantation reports · 2023Article
- Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research.Frontiers in cardiovascular medicine · 2023Article
- Development of a cardiovascular magnetic resonance-compatible large animal isolated heart model for direct comparison of beating and arrested hearts.NMR in biomedicine · 2022Article
- Slowing down as we age: aging of the cardiac pacemaker's neural control.GeroScience · 2022Review
- Septaly Oriented Mild Aortic Regurgitant Jets Negatively Influence Left Ventricular Blood Flow-Insights From 4D Flow MRI Animal Study.Frontiers in cardiovascular medicine · 2021Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac magnetic resonance imaging (MRI) in large animals is cumbersome for various reasons, including ethical considerations, costs of housing and maintenance, and need for anaesthesia. Our primary purpose was to show the feasibility of an isolated beating pig heart model for four-dimensional (4D) flow MRI for investigating intracardiac blood flow patterns and flow parameters using slaughterhouse side products. In addition, the feasibility of evaluating transcatheter aortic valve replacement (TAVR) in the model was investigated.
methodsSeven slaughterhouse pig hearts were installed in the MRI-compatible isolated beating pig heart platform. First, Langendorff perfusion mode was established; then, the system switched to working mode, in which blood was actively pumped by the left ventricle. A pacemaker ensured a stable HR during 3-T MRI scanning. All hearts were submitted to human physiological conditions of cardiac output and stayed vital for several hours. Aortic flow was measured from which stroke volume, cardiac output, and regurgitation fraction were calculated.
results4D flow MRI acquisitions were successfully conducted in all hearts. Stroke volume was 31 ± 6 mL (mean ± standard deviation), cardiac output 3.3 ± 0.9 L/min, and regurgitation fraction 16% ± 9%. With 4D flow, intracardiac and coronary flow patterns could be visualised in all hearts. In addition, we could study valve function and regurgitation in two hearts after TAVR.
conclusionsThe feasibility of 4D flow MRI in an isolated beating pig heart loaded to physiological conditions was demonstrated. The platform is promising for preclinical assessment of cardiac blood flow and function.
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