SynthesisClinical and experimental nephrology2020
Neutrophil-lymphocyte count ratio as a diagnostic marker for acute kidney injury: a systematic review and meta-analysis.
Synthesis in Clinical and experimental nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive and prognostic value of the neutrophil-to-lymphocyte ratio for acute kidney injury: a systematic review and meta-analysis.Clinical and experimental medicine · 2025Pooled it
- Linear correlation between white blood cell counts and the progression and prognosis of acute kidney injury.The Journal of international medical research · 2025Trial
- Rapid Diagnostics for Distinguishing Bacterial and Viral Infections: A Review of Technologies, Clinical Utility, and Stewardship Implications.Biosensors · 2026Review
- Systemic immune-inflammation index (SII): a predictor of mortality risk in pediatric acute kidney injury.Pediatric research · 2026Article
- Association between inflammatory burden index combined with D-dimer and acute kidney injury in elderly patients.Frontiers in medicine · 2026Article
- Predictability of kinetic estimated glomerular filtration rate for acute kidney injury in patients undergoing coronary artery bypass surgery.BMC nephrology · 2025Article
- Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study.Renal failure · 2024Article
- Circulating Immune Complexes and Complement Activation in Sensitized Kidney Transplant Recipients.International journal of molecular sciences · 2024Article
- Prognostic value of neutrophil-to-lymphocyte ratio on proteinuria remission in patients with idiopathic membranous nephropathy.International urology and nephrology · 2024Article
- Article
- Alterations in novel inflammatory biomarkers during perioperative cardiovascular surgeries involving cardiopulmonary bypass: a retrospective propensity score matching study.Frontiers in cardiovascular medicine · 2024Article
- Association of preoperative neutrophil-lymphocyte ratio with acute kidney injury in patients with non-cardiac surgery: difference among surgical types.International urology and nephrology · 2023Article
- Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study.Immunity & ageing : I & A · 2023Article
- Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio. Results from InCHIANTI follow-up study.Research square · 2023Article
- Systematic review of the diagnostic role of neutrophil to lymphocyte ratio in sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2023Article
- Dynamic nature and prognostic value of the neutrophil-to-lymphocyte ratio in critically ill patients with acute kidney injury on continuous renal replacement therapy: A multicenter cohort study.Frontiers in medicine · 2023Article
- Monocyte-to-lymphocyte ratio: a potential novel predictor for acute kidney injury in the intensive care unit.Renal failure · 2022Article
- The neutrophil to lymphocyte ratio and serum albumin as predictors of acute kidney injury after coronary artery bypass grafting.Scientific reports · 2022Article
- Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Increased Monocyte/Lymphocyte Ratio as Risk Marker for Cardiovascular Events and Infectious Disease Hospitalization in Dialysis Patients.Blood purification · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neutrophil-to-lymphocyte ratio (NLR) is calculated from the white cell differential blood count. Recently, NLR was identified as a potential biomarker for the prediction of acute kidney injury (AKI). We conducted this systematic review and meta-analysis to evaluate the diagnostic value of NLCR for AKI in adult patients.
methodsStudies in the PubMed, EMBASE, Web of Science and Cochrane Library databases were systematically searched from the date of database inception to February 28, 2019. The predictive value of NLR for AKI was evaluated by the pooled sensitivity, specificity, and summary receiver operating characteristic curve (SROC) analyses. Review Manager and Stata were used for all statistical analyses. The sources of potential heterogeneity were explored by a sensitivity analysis and subgroup analysis.
resultsThis meta-analysis returned 89 reports, of which 9 fulfilled the inclusion criteria, accounting for 9766 patients. Bivariate analysis yielded a mean sensitivity of 0.736 (95% CI 0.675-0.790) and specificity of 0.686 (95% CI 0.601-0.759). The SROC was 0.77 (95% CI 0.74-0.81). The studies had no significant heterogeneity (Q = 0.675, p = 0.357, I
conclusionsOur findings indicate that the NLR may be a reliable biomarker for the early detection of AKI. Our findings also provide important information and assistance for clinicians in the prediction of AKI.
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