Observational studyThe Journal of clinical endocrinology and metabolism2020
Association of Genetic Variants Related to Serum Calcium Levels with Reduced Bone Mineral Density.
Observational study in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Serum Calcium Concentration Is Associated with Bone Mineral Density and Synonymous Variants in theMedical sciences (Basel, Switzerland) · 2025Article
- Effects of bone metabolism on hematopoiesis: A Mendelian randomization study.Osteoporosis and sarcopenia · 2024Article
- Inverted U-shaped association between total testosterone with bone mineral density in men over 60 years old.BMC endocrine disorders · 2024Article
- Multiplex influences on vigilance and biochemical variables induced by sleep deprivation.Frontiers in sports and active living · 2024Article
- A diagnostic approach integrated multimodal radiomics with machine learning models based on lumbar spine CT and X-ray for osteoporosis.Journal of bone and mineral metabolism · 2023Article
- Causal association of genetically determined circulating vitamin D metabolites and calcium with multiple sclerosis in participants of European descent.European journal of clinical nutrition · 2023Article
- Methotrexate Increases Serum Calcium Levels in Patients with Rheumatoid Arthritis: A Retrospective Study at a Referral Hospital in Indonesia.Current therapeutic research, clinical and experimental · 2023Article
- A Guide for Understanding and Designing Mendelian Randomization Studies in the Musculoskeletal Field.JBMR plus · 2022Review
- Review
- Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis.Frontiers in neurology · 2022Article
- Non-linear relationship between albumin-corrected calcium and 30-day in-hospital mortality in ICU patients: A multicenter retrospective cohort study.Frontiers in endocrinology · 2022Article
- Review
- Vitamin D and COVID-19: causal factor or bystander?Postgraduate medical journal · 2021Article
- Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
contextThe role of serum calcium in bone metabolism is unknown, even though calcium/vitamin D supplementations have been widely used and are expected to improve bone health. We aim to determine the independent role of serum calcium in bone mineral density (BMD). DESIGN AND
settingTwo epidemiological analyses with 5478 and 5556 participants from the National Health and Nutrition Examination Survey (NHANES) 2003 to 2006 and the Hong Kong Osteoporosis Study (HKOS) to evaluate the cross-sectional association of serum calcium with BMD. Two-sample Mendelian randomization (MR) studies using genetic variations as instrumental variables to infer causality. Summary statistics of genome-wide association study of serum calcium (N = 39 400) and lifelong whole-body BMD (N = 66 628) were used.
main outcome measureBMD measured by dual-energy X-ray absorptiometry.
resultsIn NHANES 2003-6 and HKOS, each standard deviation (SD) increase in serum calcium was significantly associated with 0.036-0.092 SD decrease in BMD at various sites (all P < .05). In multivariable inverse-variance weighted MR analysis, genetic predisposition to higher serum calcium level was inversely associated with whole-body BMD after adjustment for serum parathyroid hormone, vitamin D, and phosphate (-0.431 SD per SD increase in serum calcium; 95% CI: -0.773 to -0.089, P = .014). Similar estimates were obtained in sensitivity analyses.
conclusionsOur study reveals that genetic predisposition to higher serum calcium level per se may have a negative impact on bone metabolism. Whether increased serum calcium caused by calcium/vitamin D supplementations would have the same negative effect on bone remains unknown, which warrants further investigation. In addition to other adverse clinical outcomes, careful use of high-dose supplementations is required.
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