Evidence map›Paper›PMID 31650121›Full record

ArticleNorthern clinics of Istanbul2019

46 XX male syndrome with hypogonadotropic hypogonadism: A case report.

Mehmet M Yalcin, Cigdem Ozkan, Mujde Akturk, Ferda Emriye Percin, Alev Altinova, Ayhan Karakoc, Goksun Ayvaz, Nuri Cakir

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Northern clinics of Istanbul, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mehmet M YalcinDepartment of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Cigdem OzkanDepartment of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Mujde AkturkDepartment of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Ferda Emriye PercinDepartment of Medical Genetics, Gazi University Faculty of Medicine, Ankara, Turkey.
Alev AltinovaDepartment of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Ayhan KarakocDepartment of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Goksun AyvazDepartment of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Nuri CakirDepartment of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Gazi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a 46 XX male syndrome diagnosed after failure of gonadotropin therapy taken for hypogonadotropic hypogonadism due to a pituitary macroadenoma. A 39-year-old man with a non-functioning pituitary macroadenoma was admitted to our clinic due to vision loss and infertility. After pituitary surgery, vision loss improved while infertility still existed. Low testosterone levels without elevated gonadotropins were established suggesting hypogonadotropic hypogonadism due to pituitary adenoma. Gonadotropin treatment was initiated. There was no response to treatment after 12 months. A karyotype analysis was ordered to investigate other causes of infertility. Karyotype analysis showed a 46 XX male syndrome that can explain the failure of gonadotropin therapy. Testosterone therapy was started instead of gonadotropin therapy. 46 XX male syndrome usually presents with hypergonadotropic hypogonadism. However, in our case, it presented with hypogonadotropic hypogonadism due to pituitary mass not responding to gonadotropin therapy. It is important to keep in mind to obtain a genetic analysis of patients whose gonadotropin therapy failed, even if their gonadotropin levels are not elevated.

Indexed as

46 XX maleHypogonadisminfertility

Identifiers

PMID31650121
PMCPMC6790926
OpenAlexW2803992520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.