Evidence map›Paper›PMID 31650053›Full record

ArticleJournal of preventive medicine and hygiene2019

HIV infection and frequency of micronucleus in human peripheral blood cells.

A Zizza, P Grima, M G Andreassi, M R Tumolo, A Borghini, A DE Donno, P Negro, M Guido

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of preventive medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

A ZizzaInstitute of Clinical Physiology, National Research Council, Lecce, Italy.
P GrimaInfectious Diseases Operative Unit, Vito Fazzi Hospital, Lecce, Italy.
M G AndreassiGenetics Unit, Institute of Clinical Physiology, National Research Council, Pisa, Italy.
M R TumoloInstitute for Research on Population and Social Policies, National Research Council, Brindisi, Italy.
A BorghiniGenetics Unit, Institute of Clinical Physiology, National Research Council, Pisa, Italy.
A DE DonnoLaboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
P NegroImmunohaematology and Transfusion Medicine Unit, Vito Fazzi Hospital, Lecce, Italy.
M GuidoLaboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
National Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePeople living with HIV have higher rates of malignancies than the general population in the era of active antiretroviral therapy (ART). Genotoxic effects of HIV infection and/or ART that can induce neoplastic development are not yet well known. A prospective cohort study to investigate DNA damage measured through the micronuclei (MN) frequency in HIV-patients has been performed.

methodsPeripheral blood mononuclear cells (PBMC) were isolated from 52 HIV-patients treated with ART and 55 healthy controls.

resultsBy the comparison of MN frequency, a significant difference between HIV-patients (15.5 ± 9.8) and controls (6.0 ± 3.6) (p < 0.001) has been revealed. In univariate linear regression analysis, HCV infection (r = 0.31; p < 0.001), HIV-RNA (r = 0.29; p < 0.03) and duration of infection (r = - 0.16; p < 0.25) were associated with MN frequency; while only viral load (VL) significantly correlates (r = 0.29; p < 0.05) in a multiple regression model.

conclusionsThe association of VL with MN frequency supports a genotoxic effect of HIV infection.

Indexed as

Micronuclei, Chromosome-DefectiveViral LoadAdultAnti-HIV AgentsCase-Control StudiesCoinfectionDNA DamageFemaleHepatitis C, ChronicHIV InfectionsHumansItalyMaleMiddle AgedNeoplasmsProspective StudiesAnti-HIV AgentsRNA, ViralBiomarkerCancer riskDNA damageGenetic instabilityHIV infectionMicronucleus

Identifiers

PMID31650053
PMCPMC6797881
OpenAlexW2991232682

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.