Evidence map›Paper›PMID 31650049›Full record

Observational studyJournal of preventive medicine and hygiene2019

The burden of severe cases of Influenza disease: the Friuli Venezia Giulia Region experience.

M Bassetti, M Peghin, T Gallo, C Pipan, P D'Agaro, A Sartor, T Bove, R Cocconi, E Graziano, N Castaldo

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of preventive medicine and hygiene, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Journal of preventive medicine and hygiene · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

M BassettiInfectious Diseases Division, Department of Medicine University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Italy.
M PeghinInfectious Diseases Division, Department of Medicine University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Italy.
T GalloDepartment of Prevention, Local Health Unit 4 Medio Friuli, Udine, Italy.
C PipanMicrobiology Unit, Department of Medicine University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Italy.
P D'AgaroDepartment of Medical, Surgical and Health Sciences, University of Trieste, Italy.
A SartorMicrobiology Unit, Department of Medicine University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Italy.
T BoveAnesthesiology and Intensive Care Medicine, Department of Medicine University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Italy.
R CocconiSOC Direzione Medica di Presidio, Azienda Sanitaria Universitaria Integrata di Udine, Italy.
E GrazianoInfectious Diseases Division, Department of Medicine University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Italy.
N CastaldoInfectious Diseases Division, Department of Medicine University of Udine and Azienda Sanitaria Universitaria Integrata di Udine, Italy.
University of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInfluenza is a matter of serious concern for clinicians, in both outpatient and in-hospital settings. Worldwide, the 2017-18 epidemic proved to be the most severe since 2003-04. We report a real-world experience regarding the management of patients with influenza admitted to a large teaching hospital in the Friuli Venezia Giulia region during the 2017-2018 influenza season. We also provide a practical guide for the management of hospitalized influenza patients.

methodsA retrospective observational analysis was conducted among all influenza patients requiring admission to our center during the 2017-18 season.

resultsOverall, 29 patients were admitted to the University Hospital of Udine during the 2017-18 season with a diagnosis of influenza. B virus was responsible for the majority of cases. More than 65.5% of the subjects presented with a complication. We estimated that 41.4% of the patients admitted were affected by a "severe form". All these cases required admission to the Intensive Care Unit, with 27.6% and 10.3% needing Orotracheal Intubation and Extracorporeal Membrane Oxygenation, respectively. The fatality rate was 24.1%. Notably, only 9 subjects in our cohort had been vaccinated. Based on the experience acquired during the past season, we propose a practical guide to the management of influenza cases in everyday hospital practice.

conclusionThe cornerstones of the management of all hospitalized influenza patients are the rapid identification and treatment of severe forms. Timely and strict adherence to contact and respiratory precautions are also fundamental to reducing the risk of intra-hospital outbreaks. Despite improvements in antiviral therapies and supportive measures, influenza-related morbidity and mortality remain high. In our opinion, a universal vaccination program is the only safe and effective method of filling the gap.

Indexed as

Extracorporeal Membrane OxygenationRespiration, ArtificialAdolescentAdultAgedAged, 80 and overAntiviral AgentsChildChild, PreschoolCoinfectionEarly DiagnosisEarly Medical InterventionFemaleHospitalizationHumansInfantAntiviral AgentsInfluenza VaccinesInfluenzaNeuraminidasePneumoniaRespiratory illnessVaccination

Identifiers

PMID31650049
PMCPMC6797893
OpenAlexW2985000639

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.