ArticleAlzheimer's & dementia (New York, N. Y.)2019
Sex-specific composite scales for longitudinal studies of incipient Alzheimer's disease.
Article in Alzheimer's & dementia (New York, N. Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Maximizing utility of neuropsychological measures in sex-specific predictive models of incident Alzheimer's disease in the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- MicroRNAs as potential biomarkers in temporal lobe epilepsy and mesial temporal lobe epilepsy.Neural regeneration research · 2023Review
- Anticholinergic Drug Burden and Neurocognitive Performance in the Study of Latinos-Investigation of Neurocognitive Aging.Journal of Alzheimer's disease : JAD · 2022Article
- Molecular and subregion mechanisms of episodic memory phenotypes in temporal lobe epilepsy.Brain communications · 2022Article
- Enhancing the Sensitivity of Memory Tests: Reference Data for the Free and Cued Selective Reminding Test and the Logical Memory Task from Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels.Journal of Alzheimer's disease : JAD · 2021Article
- Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy.Epilepsia · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionThe impact of Alzheimer's disease (AD) on cognitive decline differs by sex. Composite scores are useful as singular outcomes in clinical trials, yet to date these have not been developed to measure sex-specific change.
methodWe derived optimal composites from component scales available in the AD Neuroimaging Initiative (ADNI) database among cognitively normal and mild cognitively impaired subjects who are cerebrospinal fluid amyloid-β positive for early AD. Maximally sensitive composites were constructed separately for men and women using standard formulas. We compared the statistical power of the composites with the ADNI Prodromal Alzheimer's Cognitive Composite.
resultsAmong 9 cognitive measures and clinical dementia rating sum of boxes, the optimal sex-specific composites included 5 measures, including the clinical dementia rating and 4 distinct cognitive measures. The sex-specific composites consistently outperformed sex-agnostic composites and the ADNI Prodromal Alzheimer's Cognitive Composite. DISCUSSION: Sex-specific composite scales may improve the power of longitudinal studies of early AD and clinical trials.
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