Evidence map›Paper›PMID 31649853›Full record

ArticleActa pharmaceutica Sinica. B2019

Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma.

Xiyue Zhao, Xiaoyu Liu, Pengcheng Zhang, Yiran Liu, Wei Ran, Ying Cai, Junyang Wang, Yihui Zhai, Guanru Wang, Yaping Ding and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The Immune Microenvironment in Liver Cancer: From Analysis to Targeting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. An Integrated Arterial Remodeling Hydrogel for Preventing Restenosis After Angioplasty.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Xiyue ZhaoDepartment of Chemistry, Shanghai University, Shanghai 200444, China.
Xiaoyu LiuState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Pengcheng ZhangState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yiran LiuState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Wei RanState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Ying CaiState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Junyang WangState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yihui ZhaiState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Guanru WangState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yaping DingDepartment of Chemistry, Shanghai University, Shanghai 200444, China.
Yaping LiState Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Shanghai Institute of Materia Medica · CNUniversity of Chinese Academy of Sciences · CNChinese Academy of Sciences · CNShanghai University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma (HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report an injectable supramolecular peptide hydrogel as an intraperitoneal depot for localized and sustained release of triptolide for the treatment of orthotopic HCC. We chose peptide amphiphile C

Indexed as

Akt, protein kinase BANOVA, analysis of varianceAST, aspartate transaminaseATL, alanine transaminaseAUC0–13, areas under the curveAURKA, aurora A kinaseBel-7402/Luc, luciferase transfected human HCC cell line Bel-7402BUN, blood urea nitrogenC16-N, C16-GNNQQNYKD-OHC16-N/DiI, DiI-labeled C16-NC16-N/DiR, DiR-labeled C16-N hydrogelC16-N/T, triptolide-loaded peptide amphiphile-based hydrogelCAS, Chinese Academy of SciencesCD, circular dichroismCKS2, cyclin kinase subunit-2CRE, creatinineDL, drug loadingd-Luciferin, (S)-4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-thiazolecarboxylic acid potassiumDSPE-PEG, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino (polyethylene glycol)-2000]DSPE-PEG/DiI, DiI-labeled DSPE-PEGDSPE-PEG/DiR, DiR-labeled DSPE-PEG micelleDSPE-PEG/T, drug-loaded DSPE-PEG micellesEE, encapsulation efficiencyFBS, fetal bovine serumFI, fluorescence intensityFI range, fluorescence intensity rangeGEMOX, gemcitabine and oxaliplatinH&E, hematoxylin and eosinHepatocellular carcinomaHFIP, 1,1,1,3,3,3-hexafluoro-2-propanolHPLC, high-performance liquid chromatographyHydrogelLC–MS, liquid chromatography–mass spectrometryOB glue, EPIGLUsPeptide amphiphileRFI, relative fluorescence intensitySelf-assemblyTACE, transarterial chemoembolizationTEM, transmission electron microscopyTIR, tumor inhibition rateTmax, time to reach highest fluorescence intensityTriptolide

Identifiers

PMID31649853
PMCPMC6804453
OpenAlexW2950151505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.