Evidence map›Paper›PMID 31649847›Full record

ArticleActa pharmaceutica Sinica. B2019

Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-

Feng Zhou, Jingtian Mei, Xiuguo Han, Hanjun Li, Shengbing Yang, Minqi Wang, Linyang Chu, Han Qiao, Tingting Tang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 1 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 1 synthesis or guideline pooled it, 398 citations in OpenAlex.

  1. Pooled it
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  5. Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain.Proceedings of the National Academy of Sciences of the United States of America · 2026
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154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Feng ZhouShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Jingtian MeiShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Xiuguo HanShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Hanjun LiShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Shengbing YangShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Minqi WangShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Linyang ChuShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Han QiaoShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Tingting TangShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Shanghai Ninth People's Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) progression. RAW264.7 macrophages were polarized to M1/M2 subtypes then administered with different concentrations of Kin. The polarization transitions were evaluated with quantitative real-time polymerase chain reaction (qRT-PCR), confocal observation and flow cytometry analysis. The mechanism of Kin repolarizing M1 macrophages was evaluated by Western blot. Further, macrophage conditioned medium (CM) and IL-1

Indexed as

AP-1, activator protein-1Arg-1, arginase-1BV, bone volumeBV/TV, bone volume/total tissue volumeC/EBP β, CCAAT/enhancer-binding protein βChondrocytesCM, conditioned mediumDMEM, Dulbecco׳s minimum essential mediumGA, gouty arthritisH&E, hematoxylin & eosinHUVECs, human umbilical vein endothelial cellsIFN-γ, interferon-γiNOS, inducible nitric oxide synthaseIRF4, interferon regulatory factor 4Kin, kinsenosideKinsenosideLPS, lipopolysaccharidesMacrophagesMAPK, mitogen-activated protein kinasesMSU, monosodium urateNF-κB, nuclear factor-κBNSAIDs, non-steroidal anti-inflammatory drugsOA, osteoarthritisOARSI, Osteoarthritis Research Society InternationalOsteoarthritisPolarizationPPARγ, peroxisome proliferator-activated receptor γRA, rheumatoid arthritisROS, reactive oxygen speciesS&F, safranin O-fast greenTb.N, trabecular numberTb.Sp, trabecular separationTb.Th, trabecular thicknessTLRs, toll-like receptorsTNF-α, tumor necrosis factor-α

Identifiers

PMID31649847
PMCPMC6804452
OpenAlexW2917542703

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.