Evidence map›Paper›PMID 31649834›Full record

ReviewAlcohol research : current reviews2019

Alcohol Use Disorder and Depressive Disorders.

R Kathryn McHugh, Roger D Weiss

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alcohol research : current reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06620276 (Acceptance and Commitment Therapy in Patients With Alcohol Use Disorder and Comorbid Treatment-Resistant Depression Who Are Undergoing Ketamine Intervention), which is not on this map. Cited by 252 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06620276 narecruitingnot on this mapstarted 2025, after this paper: background citation

Acceptance and Commitment Therapy in Patients With Alcohol Use Disorder and Comorbid Treatment-Resistant Depression Who Are Undergoing Ketamine Intervention: A Feasibility Study

TypeinterventionalSponsorCentre hospitalier de l'Université de Montréal (CHUM)Ran2025 to 2028Enrolled30ConditionsDepression - Major Depressive Disorder, Alcohol Use DisorderArmsAcceptance and Commitment Therapy, Ketamine
3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  9. Emergency department-initiated oral naltrexone for patients with moderate to severe alcohol use disorder: A pilot feasibility study.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2025
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192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

R Kathryn McHughR. Kathryn McHugh, Ph.D., is an assistant professor in the Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, and an associate psychologist in the Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts. Roger D. Weiss, M.D., is a professor in the Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, and the chief of the Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts.
Roger D WeissR. Kathryn McHugh, Ph.D., is an assistant professor in the Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, and an associate psychologist in the Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts. Roger D. Weiss, M.D., is a professor in the Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, and the chief of the Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts.

Funding

Mentoring in Drug Abuse and Dual Diagnosis ResearchK24DA022288 · NIDA · MCLEAN HOSPITAL · PI WEISS, ROGER D. · 2007 to 2016
$1.8M
GENDER DIFFERENCES IN MECHANISMS OF RECOVERY FROM OPIOID USE DISORDER AND ANXIETYK23DA035297 · NIDA · MCLEAN HOSPITAL · PI MCHUGH, REBECCA KATHRYN · 2014 to 2018
$959k
NIDA NIH HHS K23 DA035297NIDA NIH HHS K24 DA022288
6 · The paper itself

Abstract

Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance. The aim of this review is to characterize the prevalence, course, and treatment of co-occurring AUD and depressive disorders. Studies have indicated that the co-occurrence of AUD and depressive disorders is associated with greater severity and worse prognosis for both disorders. Both pharmacologic and behavioral treatments have demonstrated efficacy for this population. However, treatment response is somewhat modest, particularly for drinking outcomes, highlighting the importance of further research on the etiology and treatment of co-occurring AUD and depressive disorders. Key future directions include studies to understand the heterogeneity of both AUD and depressive disorders, research on novel treatment approaches to enhance outcomes, and better understanding of sex and gender differences.

Indexed as

AlcoholismComorbidityDepressive DisorderHumansPrevalencePrognosisalcohol use disorderco-occurring disordersdepressiondysthymiasex differences

Identifiers

PMID31649834
PMCPMC6799954

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.