Evidence map›Paper›PMID 31649681›Full record

ArticleFrontiers in immunology2019

Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques.

Lauren L Truitt, Di Yang, Diego A Espinoza, Xing Fan, Daniel R Ram, Matilda J Moström, Dollnovan Tran, Lesli M Sprehe, R Keith Reeves, Robert E Donahue and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
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  7. Evaluation of diversity indices to estimate clonal dominance in gene therapy studies.Molecular therapy. Methods & clinical development · 2023
    Article
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  14. Interrogation of clonal tracking data usingNature computational science · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Lauren L TruittTranslational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Di YangTranslational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Diego A EspinozaTranslational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Xing FanTranslational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Daniel R RamCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Matilda J MoströmTulane National Primate Research Center, Covington, LA, United States.
Dollnovan TranTulane National Primate Research Center, Covington, LA, United States.
Lesli M SpreheTulane National Primate Research Center, Covington, LA, United States.
R Keith ReevesCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Robert E DonahueTranslational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Amitinder KaurTulane National Primate Research Center, Covington, LA, United States.
Cynthia E DunbarTranslational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Chuanfeng WuTranslational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Tulane University · USNational Institutes of Health · USBeth Israel Deaconess Medical Center · USNational Heart Lung and Blood Institute · USUnion Hospital · CNUniversity of Pennsylvania · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
Mechanisms of innate modulation of SIV reservoirs and opportunistic disease in the oral cavityR01DE026014 · NIDCR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI REEVES, ROGER KEITH · 2016 to 2020
$3.4M
NIAID NIH HHS T32 AI007387NIDCR NIH HHS R01 DE026014NIH HHS P51 OD011104
6 · The paper itself

Abstract

Recent functional, gene expression, and epigenetic studies have suggested the presence of a subset of mature natural killer (NK) cells responsible for maintaining NK cell memory. The lack of endogenous clonal markers in NK cells impedes understanding the genesis of these cell populations. In humans, primates, and mice, this phenotype and memory or adaptive functions have been strongly linked to cytomegalovirus or related herpes virus infections. We have used transplantation of lentivirally-barcoded autologous hematopoietic stem and progenitor cells (HSPC) to track clonal hematopoiesis in rhesus macaques and previously reported striking oligoclonal expansions of NK-biased barcoded clones within the CD56

Indexed as

Cell ProliferationImmunity, CellularAnimalsCD56 AntigenCytomegalovirusCytomegalovirus InfectionsFemaleKiller Cells, NaturalMacaca mulattaMaleReceptors, IgGCD56 AntigenReceptors, IgGadaptive memorybarcodingclonalitycytomegalovirusNK cells

Identifiers

PMID31649681
PMCPMC6794559
OpenAlexW2980087747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.