Evidence map›Paper›PMID 31649662›Full record

ArticleFrontiers in immunology2019

Bacille Calmette-Guérin Vaccine Strain Modulates the Ontogeny of Both Mycobacterial-Specific and Heterologous T Cell Immunity to Vaccination in Infants.

Agano Kiravu, Sophia Osawe, Anna-Ursula Happel, Trishana Nundalall, Jerome Wendoh, Sophie Beer, Nobomi Dontsa, Olatogni Berenice Alinde, Sikiratu Mohammed, Pam Datong and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 5 countries.

Agano KiravuDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Sophia OsaweInstitute of Human Virology Nigeria, Abuja, Nigeria.
Anna-Ursula HappelDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Trishana NundalallDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Jerome WendohDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Sophie BeerFaculty of Biological Sciences, Friedrich Schiller University, Jena, Germany.
Nobomi DontsaDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Olatogni Berenice AlindeDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Sikiratu MohammedInstitute of Human Virology Nigeria, Abuja, Nigeria.
Pam DatongInstitute of Human Virology Nigeria, Abuja, Nigeria.
D William CameronDivisions of Infectious Diseases and Respirology, University of Ottawa at the Ottawa Hospital, Ottawa, ON, Canada.
Kenneth RosenthalDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Alash'le AbimikuInstitute of Human Virology Nigeria, Abuja, Nigeria.
Heather B JaspanDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Clive M GrayDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAInstitute of Human Virology · NGFriedrich Schiller University Jena · DEGroote Schuur Hospital · ZAMcMaster University · CAUniversity of Ottawa · CA

Funding

Mucosal microbiome and vaccine responses in HIV-exposed African infantsR01AI120714 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI JASPAN, HEATHER BERYL · 2016 to 2020
$2.2M
Mechanisms of altered immune responses in HIV exposed infantsR21HD083344 · NICHD · UNIVERSITY OF CAPE TOWN · PI GRAY, CLIVE MAURICE, JASPAN, HEATHER BERYL · 2015 to 2016
$415k
NIAID NIH HHS R01 AI120714NICHD NIH HHS R21 HD083344
6 · The paper itself

Abstract

Differences in Bacille Calmette-Guérin (BCG) immunogenicity and efficacy have been reported, but various strains of BCG are administered worldwide. Since BCG immunization may also provide protection against off-target antigens, we sought to identify the impact of different BCG strains on the ontogeny of vaccine-specific and heterologous vaccine immunogenicity in the first 9 months of life, utilizing two African birth cohorts. A total of 270 infants were studied: 84 from Jos, Nigeria (vaccinated with BCG-Bulgaria) and 187 from Cape Town, South Africa (154 vaccinated with BCG-Denmark and 33 with BCG-Russia). Infant whole blood was taken at birth, 7, 15, and 36 weeks and short-term stimulated (12 h)

Indexed as

Immunity, CellularImmunity, HeterologousAge FactorsAntigens, BacterialBCG VaccineCytokinesHumansInfantMycobacteriumMycobacterium InfectionsNigeriaSouth AfricaT-Cell Antigen Receptor SpecificityT-LymphocytesT-Lymphocyte SubsetsVaccinationAntigens, BacterialBCG VaccineCytokinesAfricaBCGimmunogenicityontogenyPertussis vaccineT cellsTetanus vaccinevaccine strain

Identifiers

PMID31649662
PMCPMC6793433
OpenAlexW2977856690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.