Evidence map›Paper›PMID 31649659›Full record

ReviewFrontiers in immunology2019

CD4CD8αα IELs: They Have Something to Say.

Chao Zhou, Yuan Qiu, Hua Yang

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Pathways and mechanisms of CD4Trends in immunology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chao ZhouDepartment of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
Yuan QiuDepartment of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.
Hua YangDepartment of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine play a critical role in maintaining the immune balance of the gut. CD4CD8αα IELs are one of the most important types of IELs, and they play an irreplaceable role in maintaining the balance of the intestinal immune system. CD4CD8αα IELs are often regarded as a special subtype of CD4

Indexed as

AnimalsCD4 AntigensCD8 AntigensHumansInflammatory Bowel DiseasesIntraepithelial LymphocytesMiceT-Lymphocytes, CytotoxicCD4 AntigensCD8 antigen, alpha chainCD8 AntigensCD4CD8αα intestinal intraepithelial lymphocytes (CD4CD8αα IELs)inflammatory bowel disease (IBD)intestinal microbestranscription factorsvitamin D receptor (VDR)

Identifiers

PMID31649659
PMCPMC6794356

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.