Evidence map›Paper›PMID 31649625›Full record

ArticleFrontiers in microbiology2019

An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation.

Emma Poole, Christopher J Z Huang, Jessica Forbester, Miri Shnayder, Aharon Nachshon, Baraa Kweider, Anna Basaj, Daniel Smith, Sarah Elizabeth Jackson, Bin Liu and 10 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Mechanisms and Determinants of CMV Reactivation in Kidney Transplantation.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Bromodomain proteins regulate human cytomegalovirus latency and reactivation allowing epigenetic therapeutic intervention.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. CD34Journal of virology · 2021
    Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Emma PooleDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Christopher J Z HuangDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Jessica ForbesterDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.
Miri ShnayderDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Aharon NachshonDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Baraa KweiderDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Anna BasajDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Daniel SmithDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Sarah Elizabeth JacksonDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Bin LiuDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Joy ShihDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Fedir N KiskinDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
K RocheCleveland Clinic, Lerner Research Institute, Cleveland, OH, United States.
E MurphyCleveland Clinic, Lerner Research Institute, Cleveland, OH, United States.
Mark R WillsDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Nicholas W MorrellDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Gordon DouganDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Noam Stern-GinossarDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Amer A RanaDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
John SinclairDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.

Funding

British Heart Foundation CH/09/001/25945British Heart Foundation PG/14/31/30786Medical Research Council MR/K021087/1Medical Research Council MR/S00081X/1
6 · The paper itself

Abstract

Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be important for HCMV latent carriage and reactivation

Indexed as

C2-iPSCsdendritic cellsendothelial progenitor cellshuman cytomegalovirusinduced pluripotent stem cellslatencymyeloidviral carriage

Identifiers

PMID31649625
PMCPMC6795026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.