Evidence map›Paper›PMID 31649623›Full record

ArticleFrontiers in endocrinology2019

Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2.

Petr Pompach, Cristina M Viola, Jelena Radosavljević, Jingjing Lin, Jiří Jiráček, Andrzej M Brzozowski, Irena Selicharová

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Tandem mass spectrometry fragmentation patterns of sulfo-SDA cross-linked peptides.European journal of mass spectrometry (Chichester, England) · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Petr PompachInstitute of Microbiology, Czech Academy of Sciences, Prague, Czechia.
Cristina M ViolaYork Structural Biology Laboratory, Department of Chemistry, The University of York, York, United Kingdom.
Jelena RadosavljevićInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia.
Jingjing LinInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia.
Jiří JiráčekInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia.
Andrzej M BrzozowskiYork Structural Biology Laboratory, Department of Chemistry, The University of York, York, United Kingdom.
Irena SelicharováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czechia.

Funding

Medical Research Council MR/K000179/1Medical Research Council MR/R009066/1
6 · The paper itself

Abstract

Structural details of changes accompanying interaction between insulin-related hormones and their binding partners are often enigmatic. Here, cross-linking/mass spectrometry could complement structural techniques and reveal details of these protein-protein interfaces. We used such approach to clarify missing structural description of the interface in human insulin-like growth factor (IGF-1):

Indexed as

cross-linkingdiazirine ringIGF-1Imp-L2mass spectrometry

Identifiers

PMID31649623
PMCPMC6794382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.