ArticleFrontiers in psychiatry2019
Reduced Brain Activity in the Right Putamen as an Early Predictor for Treatment Response in Drug-Naive, First-Episode Schizophrenia.
Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies.Frontiers in psychiatry · 2024Pooled it
- A Meta-Analysis of Neural Correlates of Reward Anticipation in Individuals at Clinical Risk for Schizophrenia.The international journal of neuropsychopharmacology · 2023Pooled it
- Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation.Frontiers in psychiatry · 2022Pooled it
- Increased regional homogeneity modulated by metacognitive training predicts therapeutic efficacy in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021Trial
- An Epicenter-guided computational framework for personalized target of repetitive transcranial magnetic stimulation in schizophrenia.NeuroImage. Clinical · 2026Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Multi-feature fusion RFE random forest for schizophrenia classification and treatment response prediction.Scientific reports · 2025Article
- Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders.Frontiers in psychiatry · 2024Article
- Abnormalities of Regional Brain Activity in Patients With Schizophrenia: A Longitudinal Resting-State fMRI Study.Schizophrenia bulletin · 2023Article
- Resting-state brain functional alterations and their genetic mechanisms in drug-naive first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Deviant spontaneous neural activity as a potential early-response predictor for therapeutic interventions in patients with schizophrenia.Frontiers in neuroscience · 2023Article
- Frontal lobe fALFF measured from resting-state fMRI as a prognostic biomarker in first-episode psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.Schizophrenia (Heidelberg, Germany) · 2022Review
- Alterations in Spontaneous Brain Activity in Drug-Naïve First-Episode Schizophrenia: An Anatomical/Activation Likelihood Estimation Meta-Analysis.Psychiatry investigation · 2022Article
- Treatment Effect of Long-Term Antipsychotics on Default-Mode Network Dysfunction in Drug-Naïve Patients With First-Episode Schizophrenia: A Longitudinal Study.Frontiers in pharmacology · 2022Article
- Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia.Neural plasticity · 2021Observational
- The Effects of Antipsychotic Treatment on the Brain of Patients With First-Episode Schizophrenia: A Selective Review of Longitudinal MRI Studies.Frontiers in psychiatry · 2021Review
- A Multimodal Fusion Analysis of Pretreatment Anatomical and Functional Cortical Abnormalities in Responsive and Non-responsive Schizophrenia.Frontiers in psychiatry · 2021Article
- Thalamus is a common locus of reading, arithmetic, and IQ: Analysis of local intrinsic functional properties.Brain and language · 2020Article
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Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antipsychotic medications can have a significant effect on brain function after only several days of treatment. It is unclear whether such an acute effect can serve as an early predictor for treatment response in schizophrenia. Thirty-two patients with drug-naive, first-episode schizophrenia and 32 healthy controls underwent resting-state functional magnetic resonance imaging. Patients were treated with olanzapine and were scanned at baseline and 1 week of treatment. Healthy controls were scanned once at baseline. Symptom severity was assessed within the patient group using the Positive and Negative Syndrome Scale (PANSS) at three time points (baseline, 1 week of treatment, and 8 weeks of treatment). The fractional amplitude of low frequency fluctuation (fALFF) and support vector regression (SVR) methods were used to analyze the data. Compared with the control group, the patient group showed increased levels of fALFF in the bilateral putamen at baseline. After 1week of olanzapine treatment, the patient group showed decreased levels of fALFF in the right putamen relative to those at baseline. The SVR analysis found a significantly positive relationship between the reduction in fALFF after 1 week of treatment and the improvement in positive symptoms after 8 weeks of treatment (
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