Evidence map›Paper›PMID 31649497›Full record

ArticleFrontiers in neuroscience2019

Peripheral Humoral Immune Response Is Associated With the Non-motor Symptoms of Parkinson's Disease.

Congcong Sun, Wenfei Yu, Zhenxiang Zhao, Chengyuan Song, Ying Liu, Guoyong Jia, Xingbang Wang, Yiming Liu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  14. Neuroinflammatory Responses and Parkinson' Disease: Pathogenic Mechanisms and Therapeutic Targets.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Congcong SunDepartment of Neurology, Qilu Hospital, Shandong University, Jinan, China.
Wenfei YuDepartment of Neurology, Qilu Hospital, Shandong University, Jinan, China.
Zhenxiang ZhaoDepartment of Neurology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Chengyuan SongDepartment of Neurology, Qilu Hospital, Shandong University, Jinan, China.
Ying LiuDepartment of Neurology, Qilu Hospital, Shandong University, Jinan, China.
Guoyong JiaDepartment of Neurology, Qilu Hospital, Shandong University, Jinan, China.
Xingbang WangDepartment of Neurology, Qilu Hospital, Shandong University, Jinan, China.
Yiming LiuDepartment of Neurology, Qilu Hospital, Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-motor symptoms are common in Parkinson's disease (PD) and can even be used as part of the supportive criteria for diagnosis. Chronic inflammation is involved in every stage of PD. Disorders of the immune system affect the peripheral blood. Whether the humoral immune response is associated with the non-motor symptoms of PD remains unknown.

methodsMann-Whitney tests and Bonferroni correction were used to compare the serum levels of IgG, IgA, IgM, C3, and C4 between 180 sporadic PD patients and 187 healthy controls. Multiple regression models were conducted to assess the associations among these indicators of humoral immunity and the clinical features of PD patients.

resultsMale PD patients had lower levels of C3 and C4 than healthy controls [0.87 (0.22) vs. 0.96 (0.19); 0.19 (0.06) vs. 0.22 (0.07), respectively, Pc < 0.01] and lower levels of C3 than female PD patients [0.87 (0.22) vs. 1.02 (0.23), Pc < 0.01]. Patients suffering from attention/memory problems had significantly lower levels of IgA and C3 than those without these problems [1.92 (1.21) vs. 2.57 (0.76); 0.89 (0.24) vs. 0.97 (0.24), respectively, Pc < 0.04]. In addition, serum IgG levels were negatively associated with mood/cognition problem scores and were positively associated with gastrointestinal tract problem scores (adjusted

conclusionThe peripheral humoral immune response might be correlated with the non-motor symptoms of PD.

Indexed as

humoral immunitynon-motor symptomsParkinson’s diseaseserum complementserum immunoglobulin

Identifiers

PMID31649497
PMCPMC6795918

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.