ArticleCommunications in statistics: theory and methods2019
Estimation of Multi-state Models with Missing Covariate Values Based on Observed Data Likelihood.
Article in Communications in statistics: theory and methods, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Continuous-time multi-state models are commonly used to study diseases with multiple stages. Potential risk factors associated with the disease are added to the transition intensities of the model as covariates, but missing covariate measurements arise frequently in practice. We propose a likelihood-based method that deals efficiently with a missing covariate in these models. Our simulation study showed that the method performs well for both 'missing completely at random' and 'missing at random' mechanisms. We also applied our method to a real dataset, the Einstein Aging Study.
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