Evidence map›Paper›PMID 31649328›Full record

ArticleScientific reports2019

ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges.

Arijita Jash, You W Zhou, Diana K Gerardo, Tyler J Ripperger, Bijal A Parikh, Sytse Piersma, Deepa R Jamwal, Pawel R Kiela, Adrianus C M Boon, Wayne M Yokoyama and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Antibody Responses to SARS-CoV-2: Let's Stick to Known Knowns.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Arijita JashDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States of America.
You W ZhouDepartment of Medicine, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States of America.ORCID http://orcid.org/0000-0002-4172-3681
Diana K GerardoDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
Tyler J RippergerDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
Bijal A ParikhDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States of America.ORCID http://orcid.org/0000-0003-2490-8294
Sytse PiersmaDepartment of Medicine, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States of America.ORCID http://orcid.org/0000-0002-5379-3556
Deepa R JamwalDepartment of Pediatrics, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
Pawel R KielaDepartment of Pediatrics, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
Adrianus C M BoonDepartment of Medicine, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States of America.
Wayne M YokoyamaDepartment of Medicine, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States of America.ORCID http://orcid.org/0000-0002-0566-7264
Chyi S HsiehDepartment of Medicine, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States of America.
Deepta BhattacharyaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States of America. deeptab@email.arizona.edu.
Washington University in St. Louis · USUniversity of Arizona · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITYR01AI099108 · NIAID · WASHINGTON UNIVERSITY · PI Deepta Bhattacharya · 2012 to 2026
$6.4M
NATURAL KILLER CELL CONTROL OF MURINE CYTOMEGALOVIRUS INFECTIONR01AI131680 · NIAID · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 2017 to 2025
$6.0M
GLUCOSE AND AMINO ACID CATABOLISM IN PLASMA CELL BIOLOGYR01AI129945 · NIAID · UNIVERSITY OF ARIZONA · PI Deepta Bhattacharya · 2018 to 2026
$4.8M
The Role of IFI35 in Innate Immunity and Influenza PathogenesisR01AI118938 · NIAID · WASHINGTON UNIVERSITY · PI BOON, ADRIANUS CM · 2016 to 2020
$1.9M
Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training ProgramT32AG058503 · NIA · UNIVERSITY OF ARIZONA · PI Kristian Paul Doyle, JANKO Z. NIKOLICH · 2019 to 2026
$1.9M
Modulation of dendritic cell function in the pathogenesis of Inflammatory Bowel DiseasesR01DK109711 · NIDDK · UNIVERSITY OF ARIZONA · PI GHISHAN, FAYEZ KHALAF, KIELA, PAWEL R · 2016 to 2020
$1.7M
Evaluation of Antigen-Specific Immune Interactions with Commensal Bacteria in NeonatesU01AI131349 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S · 2017 to 2021
$1.5M
MECHANISMS OF THE NATURAL KILLER CELL ANTIVIRAL EFFECTOR RESPONSEK08AI104991 · NIAID · WASHINGTON UNIVERSITY · PI PARIKH, BIJAL A. · 2013 to 2017
$844k
NCI NIH HHS P30 CA023074NIAID NIH HHS K08 AI104991NIAID NIH HHS R01 AI099108NIAID NIH HHS R01 AI118938NIAID NIH HHS R01 AI129945NIAID NIH HHS R01 AI131680NIAID NIH HHS U01 AI131349NIA NIH HHS T32 AG058503NIDDK NIH HHS R01 DK109711U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI99109
6 · The paper itself

Abstract

ZBTB32 is a transcription factor that is highly expressed by a subset of memory B cells and restrains the magnitude and duration of recall responses against hapten-protein conjugates. To define physiological contexts in which ZBTB32 acts, we assessed responses by Zbtb32

Indexed as

AnimalsAntibodies, ViralAntibody FormationBone Marrow CellsHerpesviridae InfectionsImmunologic MemoryMiceMice, KnockoutMice, TransgenicMuromegalovirusRepressor ProteinsAntibodies, ViralRepressor ProteinsRog protein, mouse

Identifiers

PMID31649328
PMCPMC6813321
OpenAlexW2981620243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.