Evidence map›Paper›PMID 31649323›Full record

ArticleSpinal cord2020

Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury.

Reza Ehsanian, Jenny Haefeli, Nhung Quach, Jacob Kosarchuk, Dolores Torres, Ellen D Stuck, Jessica Endo, James D Crew, Benjamin Dirlikov, Jacqueline C Bresnahan and 3 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Spinal cord, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Diagnostic blood RNA profiles for human acute spinal cord injury.The Journal of experimental medicine · 2021
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Reza EhsanianRehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, USA.
Jenny HaefeliBrain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Nhung QuachRehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, USA.
Jacob KosarchukEastern Virginia Medical School, Norfolk, VA, USA.
Dolores TorresBrain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Ellen D StuckBrain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Jessica EndoBrain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
James D CrewDepartment of Physical Medicine and Rehabilitation, Santa Clara Valley Medical Center, San Jose, CA, USA.
Benjamin DirlikovRehabilitation Research Center, Santa Clara Valley Medical Center, San Jose, CA, USA.ORCID http://orcid.org/0000-0002-9987-5178
Jacqueline C BresnahanBrain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Michael S BeattieBrain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9463-3631
Adam R FergusonBrain and Spinal Injury Center, Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Stephen L McKennaDepartment of Neurosurgery, Stanford University, Stanford, CA, USA. stephen.mckenna@hhs.sccgov.org.
University of California, San Francisco · USSanta Clara Valley Medical Center · USEastern Virginia Medical School · USUniversity of New Mexico · US

Funding

Bioinformatics For Translational Spinal Cord Injury ResearchR01NS067092 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERGUSON, ADAM R · 2010 to 2014
$1.6M
NINDS NIH HHS R01 NS067092U.S. Department of Defense (DOD) SC120159U.S. Department of Defense (DOD) W81XWH-13-1-0297
6 · The paper itself

Abstract

STUDY

designRetrospective analysis.

objectiveTo assess the impact of mean arterial blood pressure (MAP) during surgical intervention for spinal cord injury (SCI) on motor recovery.

settingLevel-one Trauma Hospital and Acute Rehabilitation Hospital in San Jose, CA, USA.

methodsTwenty-five individuals with traumatic SCI who received surgical and acute rehabilitation care at a level-one trauma center were included in this study. The Surgical Information System captured intraoperative MAPs on a minute-by-minute basis and exposure was quantified at sequential thresholds from 50 to 104 mmHg. Change in International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor score was calculated based on physiatry evaluations at the earliest postoperative time and at discharge from acute rehabilitation. Linear regression models were used to estimate the rate of recovery across the entire MAP range.

resultsAn exploratory analysis revealed that increased time within an intraoperative MAP range (70-94 mmHg) was associated with ISNCSCI motor score improvement. A significant regression equation was found for the MAP range 70-94 mmHg (F[1, 23] = 5.07, r

conclusionsHypertension as well as hypotension during surgery may impact the trajectory of recovery in individuals with SCI, and there may be a direct relationship between intraoperative MAP and motor recovery.

Indexed as

Arterial PressureRecovery of FunctionAdultBlood Pressure DeterminationFemaleHumansMaleMiddle AgedMonitoring, IntraoperativeRetrospective StudiesSpinal Cord InjuriesTime Factors

Identifiers

PMID31649323
PMCPMC7062632
OpenAlexW3205617666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.