Evidence map›Paper›PMID 31649277›Full record

ArticleInternational journal of obesity (2005)2020

Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program.

Frances A Tylavsky, Assiamira Ferrara, Diane J Catellier, Emily Oken, Xiuhong Li, Andrew Law, Dana Dabelea, Andrew Rundle, Diane Gilbert-Diamond, Marie-France Hivert and 19 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in International journal of obesity (2005), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03061890 (Developmental Impact of Neonatal Intensive Care Unit), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03061890 completednot on this map

Developmental Impact of Neonatal Intensive Care Unit (NICU) Exposures: Environmental Influences on Child Health Outcomes (ECHO)

Typeobservational_patient_registrySponsorAlbert Einstein College of MedicineRan2017 to 2023Enrolled600ConditionsPrematurity
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Access to bike lanes and childhood obesity: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cohort Profile Update: Project Viva Offspring.International journal of epidemiology · 2024
    Article
  8. Built environment and childhood obesity.World journal of clinical pediatrics · 2024
    Review
  9. Article
  10. Article
  11. Cohort Profile Update: Project Viva mothers.International journal of epidemiology · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Maternal childhood trauma and prenatal stressors are associated with child behavioral health.Journal of developmental origins of health and disease · 2022
    Article
  19. Article
  20. Fetal programming of human energy homeostasis brain networks: Issues and considerations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 1 country.

Frances A TylavskyDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Assiamira FerraraDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Diane J CatellierRTI International, Research Triangle Park, Triangle Park, NC, USA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Xiuhong LiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Andrew LawDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Dana DabeleaDepartments of Epidemiology and Pediatrics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Andrew RundleDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Diane Gilbert-DiamondDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Carrie V BretonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Andrea E Cassidy-BushrowDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.ORCID http://orcid.org/0000-0001-8272-4448
Noel T MuellerWelch Center for Epidemiology, Prevention and Clinical Research, Johns Hopkins University Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kelly J HuntDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
S Sonia ArteagaNational Heart, Lung, and Blood Institute, Bethesda, MD, USA.
Tania LomboNIH Office of the Director, ECHO Program, Bethesda, MD, USA.
Somdat MahabirEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Doug RudenDepartment of Obstetrics and Gynecology, Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.
Katherine SauderDepartments of Pediatrics and Epidemiology, University of Colorado, Denver, CO, USA.ORCID http://orcid.org/0000-0002-8473-8015
Monique M HeddersonDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Yeyi ZhuDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Sarah PolkDepartment of Pediatrics and Centro SOL, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Nicole L MihalopoulosDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Miriam VosDepartment of Pediatrics, Emory University, Atlanta, GA, USA.
Lee PylesDepartment of Pediatrics, West Virginia University School of Medicine, Morgantown, WV, USA.
Mary RoaryNational Institute of Nursing Research and Environmental Influences on Child Health Outcomes Program, National Institutes of Health, Rockville, MD, USA.
Judy AschnerDepartment of Pediatrics and Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Leonardo TrasandeDepartments of Pediatrics, Environmental Medicine and Population Health, NYU School of Medicine, New York, NY, USA. leonardo.trasande@nyumc.org.ORCID http://orcid.org/0000-0002-1928-597X
Johns Hopkins University · USKaiser Permanente · USDartmouth College · USHarvard University · USNational Institutes of Health · USAlbert Einstein College of Medicine · USColorado School of Public Health · USColumbia University · USEmory University · USHenry Ford Hospital · USMedical University of South Carolina · USNational Heart Lung and Blood Institute · USNew York University · USOffice of the Director · USRTI International · USUniversity of Colorado Denver · USUniversity of Southern California · USUniversity of Tennessee Health Science Center · USUniversity of Utah · USWayne State University · US

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI JUNFENG ZHANG · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
The NYU Children’s Health & Environment Study: an ECHO CohortUG3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2016 to 2024
$26.5M
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and NeurodevelopmentUH3OD023289 · OD · KAISER FOUNDATION RESEARCH INSTITUTE · PI ASSIAMIRA FERRARA, Monique Marie Hedderson · 2018 to 2026
$25.1M
Understanding Breastfeeding Practices Among ECHO Cohort Participants Before and During/After the COVID-19 PandemicUH3OD023285 · OD · MICHIGAN STATE UNIVERSITY · PI Charles James Barone, MICHAEL R. ELLIOTT · 2018 to 2026
$24.5M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUG3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2016 to 2024
$19.3M
NHLBI NIH HHS K01 HL141589NICHD NIH HHS R01 HD034568NICHD NIH HHS UG1 HD090899NIDDK NIH HHS K01 DK120807NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK092924NIDDK NIH HHS P30 DK111022NIEHS NIH HHS P01 ES022832NIH HHS U24 OD023382NIH HHS UG1 OD024949NIH HHS UG1 OD030016NIH HHS UG3 OD023248NIH HHS UG3 OD023249NIH HHS UG3 OD023271NIH HHS UG3 OD023282NIH HHS UG3 OD023285NIH HHS UG3 OD023286NIH HHS UG3 OD023287NIH HHS UG3 OD023289NIH HHS UG3 OD023290NIH HHS UG3 OD023305NIH HHS UG3 OD023316NIH HHS UG3 OD023320NIH HHS UG3 OD035516NIH HHS UH3 OD023249NIH HHS UH3 OD023271NIH HHS UH3 OD023275NIH HHS UH3 OD023282NIH HHS UH3 OD023285NIH HHS UH3 OD023286NIH HHS UH3 OD023289NIH HHS UH3 OD023290NIH HHS UH3 OD023305NIH HHS UH3 OD023320NIH HHS UH3 OD023347
6 · The paper itself

Abstract

backgroundFew resources exist for prospective, longitudinal analysis of the relationships between early life environment and later obesity in large diverse samples of children in the United States (US). In 2016, the National Institutes of Health launched the Environmental influences on Child Health Outcomes (ECHO) program to investigate influences of environmental exposures on child health and development. We describe demographics and overweight and obesity prevalence in ECHO, and ECHO's potential as a resource for understanding how early life environmental factors affect obesity risk.

methodsIn this cross-sectional study of 70 extant US and Puerto Rico cohorts, 2003-2017, we examined age, race/ethnicity, and sex in children with body mass index (BMI) data, including 28,507 full-term post-birth to <2 years and 38,332 aged 2-18 years. Main outcomes included high BMI for age <2 years, and at 2-18 years overweight (BMI 85th to <95th percentile), obesity (BMI ≥ 95th percentile), and severe obesity (BMI ≥ 120% of 95th percentile).

resultsThe study population had diverse race/ethnicity and maternal demographics. Each outcome was more common with increasing age and varied with race/ethnicity. High BMI prevalence (95% CI) was 4.7% (3.5, 6.0) <1 year, and 10.6% (7.4, 13.7) for 1 to <2 years; overweight prevalence increased from 13.9% (12.4, 15.9) at 2-3 years to 19.9% (11.7, 28.2) at 12 to <18 years. ECHO has the statistical power to detect relative risks for 'high' BMI ranging from 1.2 to 2.2 for a wide range of exposure prevalences (1-50%) within each age group.

conclusionsECHO is a powerful resource for understanding influences of chemical, biological, social, natural, and built environments on onset and trajectories of obesity in US children. The large sample size of ECHO cohorts adopting a standardized protocol for new data collection of varied exposures along with longitudinal assessments will allow refined analyses to identify drivers of childhood obesity.

Indexed as

Child HealthPediatric ObesityAdolescentBody Mass IndexChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleMothersOverweightPrevalenceRisk Factors

Identifiers

PMID31649277
PMCPMC7060502
OpenAlexW2981853155

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.