Evidence map›Paper›PMID 31649266›Full record

SynthesisNature communications2019

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.

C S Gallagher, N Mäkinen, H R Harris, N Rahmioglu, O Uimari, J P Cook, N Shigesi, T Ferreira, D R Velez-Edwards, T L Edwards and 27 more

Erratum issuedOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 96 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 6 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 6 syntheses or guidelines pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Building Disease Models for Endometriosis: iPSCs as Game-Changers.International journal of molecular sciences · 2026
    Review
  13. Article
  14. Polymorphism of theLife (Basel, Switzerland) · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors at 15 institutions in 4 countries.

C S Gallagher *Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
N Mäkinen *Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. netta_makinen@dfci.harvard.edu.
H R Harris *Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
N Rahmioglu *Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
O UimariEndometriosis CaRe Centre, Nuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.ORCID http://orcid.org/0000-0002-8954-2900
J P CookDepartment of Biostatistics, University of Liverpool, Liverpool, L69 3GL, UK.
N ShigesiEndometriosis CaRe Centre, Nuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
T FerreiraWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
D R Velez-EdwardsVanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
T L EdwardsDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.ORCID http://orcid.org/0000-0003-4318-6119
S MortlockInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.
Z RuhiogluDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0002-0256-522X
F DayMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-3789-7651
C M BeckerEndometriosis CaRe Centre, Nuffield Department of Women's and Reproductive Health, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.ORCID http://orcid.org/0000-0002-9870-9581
V KarhunenCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, 90220, Oulu, Finland.
H MartikainenDepartment of Obstetrics and Gynecology, Oulu University Hospital and PEDEGO Research Unit & Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90220, Oulu, Finland.
M-R JärvelinCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, 90220, Oulu, Finland.ORCID http://orcid.org/0000-0002-2149-0630
R M CantorDepartment of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
P M RidkerDivision of Preventative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
K L TerryObstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
J E BuringDivision of Preventative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
S D GordonGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0001-7623-328X
S E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0003-1382-380X
G W MontgomeryInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.ORCID http://orcid.org/0000-0002-4140-8139
D R NyholtGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0001-7159-3040
D A Hinds23andMe, Mountain View, CA, 94041, USA.ORCID http://orcid.org/0000-0002-4911-803X
J Y Tung23andMe, Mountain View, CA, 94041, USA.
23andMe Research Team
J R B PerryMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
P A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0002-3887-2598
J N PainterPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
N G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.ORCID http://orcid.org/0000-0003-4069-8020
A P MorrisWellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
D I Chasman *Division of Preventative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
S A Missmer *Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
K T Zondervan *Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.ORCID http://orcid.org/0000-0002-0275-9905
C C Morton *Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. cmorton@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-2198-6756
23andMe (United States) · USBrigham and Women's Hospital · USQIMR Berghofer Medical Research Institute · AUCentre for Human Genetics · GBOulu University Hospital · FIHarvard University · USJohn Radcliffe Hospital · GBThe University of Queensland · AUUniversity of Cambridge · GBVanderbilt University Medical Center · USBroad Institute · USFred Hutch Cancer Center · USQueensland University of Technology · AUUniversity of California, Los Angeles · USUniversity of Liverpool · GB

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI Irene M. Ghobrial · 1985 to 2026
$330.6M
Modular Automated -80C Sample Storage SystemS10OD025092 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOLDENRING, JAMES RICHARD · 2019 to 2019
$2.0M
Genetic Studies of Uterine LeiomyomataR01HD060530 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI MORTON, CYNTHIA CASSON · 2010 to 2015
$1.8M
PCOS, Type II diabetes and ovarian cancer riskK22CA193860 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HARRIS, HOLLY RUTH · 2016 to 2018
$554k
Medical Research Council MC_UU_12015/2NCI NIH HHS K22 CA193860NCI NIH HHS P30 CA006516NICHD NIH HHS R01 HD060530NIH HHS S10 OD025092
6 · The paper itself

Abstract

Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10

Indexed as

AdultAtaxia Telangiectasia Mutated ProteinsEndometriosisFemaleForkhead Box Protein O1Genome-Wide Association StudyHumansLeiomyomaMendelian Randomization AnalysisMenorrhagiaMiddle AgedPolymorphism, Single NucleotideProportional Hazards ModelsReceptor, Fibroblast Growth Factor, Type 4Signal TransductionTelomeraseAtaxia Telangiectasia Mutated ProteinsATM protein, humanFGFR4 protein, humanForkhead Box Protein O1FOXO1 protein, humanReceptor, Fibroblast Growth Factor, Type 4TelomeraseTERT protein, human

Identifiers

PMID31649266
PMCPMC6813337
OpenAlexW2981968392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.