Evidence map›Paper›PMID 31649238›Full record

ArticleNature communications2019

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis.

Inês Godet, Yu Jung Shin, Julia A Ju, I Chae Ye, Guannan Wang, Daniele M Gilkes

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. CuOMikrochimica acta · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Inês GodetDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.ORCID http://orcid.org/0000-0002-4889-5144
Yu Jung ShinDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Julia A JuDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
I Chae YeDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Guannan WangDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Daniele M GilkesDepartment of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. dgilkes1@jhu.edu.ORCID http://orcid.org/0000-0003-3984-9338

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2016 to 2020
$9.9M
The role of the hypoxic ECM on integrin-induced breast cancer metastasisR00CA181352 · NCI · JOHNS HOPKINS UNIVERSITY · PI GILKES, DANIELE MARIE · 2015 to 2017
$747k
NCI NIH HHS P30 CA006973NCI NIH HHS R00 CA181352NCI NIH HHS U54 CA210173
6 · The paper itself

Abstract

Hypoxia is known to be detrimental in cancer and contributes to its development. In this work, we present an approach to fate-map hypoxic cells in vivo in order to determine their cellular response to physiological O

Indexed as

TranscriptomeAnimalsCell Line, TumorFemaleHumansMCF-7 CellsMiceMice, TransgenicNeoplasm MetastasisOptical ImagingPhenotypePrognosisReactive Oxygen SpeciesSpheroids, CellularTumor HypoxiaTumor MicroenvironmentReactive Oxygen Species

Identifiers

PMID31649238
PMCPMC6813355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.