ArticleThe Journal of biological chemistry2019
AKR1A1 is a novel mammalian
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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0cells of the map it votes in
29citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers.Nature communications · 2026Article
- Inhaled S-nitrosoglutathione in asthma: Airway SCoR2 expression and determinants of human bronchodilator response.The Journal of allergy and clinical immunology · 2026Article
- Nitric oxide drives proteomic diversity through alternative splicing.Molecular cell · 2026Article
- Protein S-Nitrosylation in Heart Failure: A Compartment-Resolved Review of Mechanisms, Evidence Boundaries, and Translational Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
- Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1.Redox biology · 2026Article
- Integration of NO and HPlant communications · 2026Review
- Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1.bioRxiv : the preprint server for biology · 2026Article
- Reactive oxygen species regulate adipose-osteogenic lineage commitment of human mesenchymal stem cells by modulating gene expression of C/EBP homology protein and aldo-keto reductase family 1 member A1.Cell & bioscience · 2025Article
- Cisd1 synergizes with Cisd2 to modulate protein processing by maintaining mitochondrial and ER homeostasis.Aging · 2025Article
- The Ever-Expanding Influence of the Endothelial Nitric Oxide Synthase.Basic & clinical pharmacology & toxicology · 2025Review
- Progress in Plant Nitric Oxide Studies: Implications for Phytopathology and Plant Protection.International journal of molecular sciences · 2025Review
- Hot to Go: The impact of protein nitrosylation on plant fertility.Plant physiology · 2025Article
- Brief Warm and Aldo-Keto Reductase FamilyInsects · 2025Article
- A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics.Frontiers in molecular biosciences · 2025Article
- Post-Translational Modifications to Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction.International journal of molecular sciences · 2024Review
- Facilitating Nitrite-Derived S-Nitrosothiol Formation in the Upper Gastrointestinal Tract in the Therapy of Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Identification of Protein Targets ofACS chemical biology · 2024Article
- Hidden networks of aberrant protein transnitrosylation contribute to synapse loss in Alzheimer's disease.Free radical biology & medicine · 2022Review
- A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.Cell reports · 2022Article
- Focus on Nitric Oxide Homeostasis: Direct and Indirect Enzymatic Regulation of Protein Denitrosation Reactions in Plants.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Colin T StomberskiDepartment of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44016.
Puneet AnandInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44016.
Nicholas M VenetosDepartment of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44016.
Alfred HausladenInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44016.
Hua-Lin ZhouDepartment of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106; Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44016.
Richard T PremontInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44016; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio 44016.
Jonathan S StamlerInstitute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44016; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio 44016; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44016. Electronic address: jonathan.stamler@case.edu.
University School · USUniversity Hospitals of Cleveland · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MRegulation of Beta-Adrenergic Receptor Signaling by S-NitrosylationP01HL075443 · NHLBI · DUKE UNIVERSITY · PI STAMLER, JONATHAN S. · 2004 to 2019
$26.1MProject 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2MRestoration and Function of S-Nitrosothiol in Stored BloodR01HL126900 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER · 2016 to 2026
$5.0MNovel Regulation of Renal Function by S-NitrosylationR01DK119506 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI JONATHAN S. STAMLER, Hualin Zhou · 2018 to 2026
$3.7MNHLBI NIH HHS P01 HL075443NHLBI NIH HHS P01 HL128192NHLBI NIH HHS R01 HL126900NIDDK NIH HHS R01 DK119506NIGMS NIH HHS T32 GM007250
Abstract
Oxidative modification of Cys residues by NO results in
Indexed as
Aldehyde OxidoreductasesAldehyde ReductaseAnimalsCoenzyme AHumansKineticsMammalsMice, Inbred C57BLMice, KnockoutNADPNitric OxideOxidation-ReductionSignal TransductionS-NitrosothiolsAKR1A1 protein, humanAkr1a1 protein, mouseAldehyde OxidoreductasesAldehyde ReductaseCoenzyme Aformaldehyde dehydrogenase, glutathione-independentNADPNitric OxideS-nitroso-coenzyme AS-NitrosothiolsAKR1A1denitrosylasedenitrosylationenzyme kineticsenzyme purificationGSNO reductasemolecular modelingmutagenesisnitric oxideS-nitroso-coenzyme A reductaseS-nitrosylation
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.