Evidence map›Paper›PMID 31649032›Full record

ArticleThe Journal of biological chemistry2019

Shox2 regulates osteogenic differentiation and pattern formation during hard palate development in mice.

Jue Xu, Linyan Wang, Hua Li, Tianfang Yang, Yanding Zhang, Tao Hu, Zhen Huang, YiPing Chen

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Convergence of external and internal stressors on a stress-responsive enhancer of theProceedings of the National Academy of Sciences of the United States of America · 2026
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  7. The subfunctionalization ofFrontiers in cell and developmental biology · 2025
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  16. Review
  17. Frontiers in cell and developmental biology · 2021
    Article
  18. Article
  19. Article
  20. CXCL12-CXCR4 Interplay Facilitates Palatal Osteogenesis in Mice.Frontiers in cell and developmental biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jue XuState Key Laboratory of Oral Diseases, Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 Sichuan, China; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041 Sichuan, China; Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Linyan WangState Key Laboratory of Oral Diseases, Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 Sichuan, China; Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Hua LiDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118; Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou, 350117 Fujian, China.
Tianfang YangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118.
Yanding ZhangSouthern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou, 350117 Fujian, China.
Tao HuState Key Laboratory of Oral Diseases, Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 Sichuan, China. Electronic address: hutao@scu.edu.cn.
Zhen HuangSouthern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou, 350117 Fujian, China. Electronic address: zhuang@fjnu.edu.cn.
YiPing ChenDepartment of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118. Electronic address: ychen@tulane.edu.
Fujian Normal University · CNTulane University · USSichuan University · CN

Funding

Molecular patterning of the hard palate during palatogenesisR01DE026482 · NIDCR · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, YIPING · 2017 to 2021
$1.8M
NIDCR NIH HHS R01 DE026482
6 · The paper itself

Abstract

During mammalian palatogenesis, cranial neural crest-derived mesenchymal cells undergo osteogenic differentiation and form the hard palate, which is divided into palatine process of the maxilla and the palatine. However, it remains unknown whether these bony structures originate from the same cell lineage and how the hard palate is patterned at the molecular level. Using mice, here we report that deficiency in

Indexed as

AnimalsBody PatterningCell DifferentiationCell LineageFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalHomeodomain ProteinsHumansMaxillaMice, KnockoutMice, TransgenicOsteogenesisPalate, HardSignal TransductionHomeodomain ProteinsShox2 protein, mousecell differentiationcraniofacial developmentepigeneticsgene regulationhard palatelineage-specific chromatin accessibilityosteogenesispatterningshort stature homeobox 2 (SHOX2)transcription factor

Identifiers

PMID31649032
PMCPMC6885637
OpenAlexW2981632373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.