Trial reportBMJ (Clinical research ed.)2019
Transmissibility and potential for disease progression of drug resistant
Trial report in BMJ (Clinical research ed.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00676754 (Epidemiology of Multidrug-Resistant Tuberculosis in Peru), which is not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiology of Multidrug-Resistant Tuberculosis in Peru
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Quantifying within-household tuberculosis transmission: a systematic review and prospective cohort study.International journal of epidemiology · 2026Pooled it
- Prevalence of non-communicable diseases among household contacts of people with tuberculosis: A systematic review and individual participant data meta-analysis.Tropical medicine & international health : TM & IH · 2024Pooled it
- Declining incidence rate of tuberculosis among close contacts in five years post-exposure: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Post-release tuberculosis risk among formerly incarcerated populations in Lima Peru.Nature communications · 2026Article
- Impact of Diabetes Mellitus in Tuberculosis (TB) Patients on TB Transmission.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Transmissibility and Disease Progression of Asymptomatic Mycobacterium tuberculosis Infection, Lima, Peru.Emerging infectious diseases · 2026Article
- The Role of Youths in Within-Household Tuberculosis Transmission: A Household Contact Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- A new method to estimate factors associated with tuberculosis transmission using whole genome sequencing and other additional metadata.Epidemiologic methods · 2026Article
- Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China.BMC microbiology · 2025Article
- The Hidden Epidemic: Post-Release Tuberculosis Risk in Formerly Incarcerated Populations.Research square · 2025Article
- Pre-treatment loss to follow-up and associated factors among drug-resistant tuberculosis patients diagnosed in Wakiso district, central Uganda.BMC infectious diseases · 2025Article
- Impact of isoniazid monoresistance on overall and vulnerable patient populations in Taiwan.Emerging microbes & infections · 2024Article
- Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.Nature communications · 2024Article
- Drug-resistant tuberculosis: a persistent global health concern.Nature reviews. Microbiology · 2024Review
- Detection of Mycobacterium tuberculosis transrenal DNA in urine samples among adults in Peru.Tuberculosis (Edinburgh, Scotland) · 2024Article
- Tuberculosis treatment loss to follow-up in children exposed at home: A prospective cohort study.Journal of global health · 2024Article
- Who Transmits Tuberculosis to Whom: A Cross-Sectional Analysis of a Cohort Study in Lima, Peru.American journal of respiratory and critical care medicine · 2024Article
- One Half of the Pair: Prioritizing Tuberculosis Transmitters for Early Detection.American journal of respiratory and critical care medicine · 2024Article
- History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.PLoS genetics · 2024Article
- Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru.Emerging infectious diseases · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo measure the association between phenotypic drug resistance and the risk of tuberculosis infection and disease among household contacts of patients with pulmonary tuberculosis.
setting106 district health centers in Lima, Peru between September 2009 and September 2012.
designProspective cohort study.
participants10 160 household contacts of 3339 index patients with tuberculosis were classified on the basis of the drug resistance profile of the patient: 6189 were exposed to drug susceptible strains of
main outcome measuresTuberculosis infection (positive tuberculin skin test) and the incidence of active disease (diagnosed by positive sputum smear or chest radiograph) after 12 months of follow-up.
resultsHousehold contacts exposed to patients with multidrug resistant tuberculosis had an 8% (95% confidence interval 4% to 13%) higher risk of infection by the end of follow-up compared with household contacts of patients with drug sensitive tuberculosis. The relative hazard of incident tuberculosis disease did not differ among household contacts exposed to multidrug resistant tuberculosis and those exposed to drug sensitive tuberculosis (adjusted hazard ratio 1.28, 95% confidence interval 0.9 to 1.83).
conclusionHousehold contacts of patients with multidrug resistant tuberculosis were at higher risk of tuberculosis infection than contacts exposed to drug sensitive tuberculosis. The risk of developing tuberculosis disease did not differ among contacts in both groups. The evidence invites guideline producers to take action by targeting drug resistant and drug sensitive tuberculosis, such as early detection and effective treatment of infection and disease.
trial registrationClinicalTrials.gov NCT00676754.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.