Evidence map›Paper›PMID 31648842›Full record

Trial reportSchizophrenia research2020

Intervention-specific patterns of cortical function plasticity during auditory encoding in people with schizophrenia.

Corby L Dale, Ethan G Brown, Alexander B Herman, Leighton B N Hinkley, Karuna Subramaniam, Melissa Fisher, Sophia Vinogradov, Srikantan S Nagarajan

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Neurobiology of schizophrenia.Current opinion in neurobiology · 2024
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Corby L DaleDepartment of Radiology and Biomedical Imaging, University of California San Francisco, United States; San Francisco Veterans' Affairs Medical Center, United States. Electronic address: corby.dale@ucsf.edu.
Ethan G BrownWeill Cornell Medical College, New York, United States.
Alexander B HermanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, United States; UCB-UCSF Graduate Program in Bioengineering, University of California, Berkeley, United States; Medical Science Training Program, University of California, San Francisco, United States.
Leighton B N HinkleyDepartment of Radiology and Biomedical Imaging, University of California San Francisco, United States.
Karuna SubramaniamDepartment of Radiology and Biomedical Imaging, University of California San Francisco, United States.
Melissa FisherSan Francisco Veterans' Affairs Medical Center, United States; Department of Psychiatry, University of California, San Francisco, United States.
Sophia VinogradovSan Francisco Veterans' Affairs Medical Center, United States; Department of Psychiatry, University of California, San Francisco, United States.
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, United States; UCB-UCSF Graduate Program in Bioengineering, University of California, Berkeley, United States.
University of California, San Francisco · USUniversity of California System · USCornell University · USUniversity of California, Berkeley · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, YADONG · 2004 to 2018
$27.1M
Using a computational and network neuroscience framework to study pharmacological manipulations of state representation processes in early psychosisP50MH119569 · NIMH · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH, Sophia Vinogradov · 2020 to 2026
$24.5M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
Cognitive Remediation of Schizophrenia in a Community Mental Health SettingR01MH068725 · NIMH · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI VINOGRADOV, SOPHIA · 2004 to 2014
$4.9M
Network Modelling of Multimodal Dynamics in Alzheimer’s Disease and DementiaRF1AG062196 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAGARAJAN, SRIKANTAN S., RAJ, ASHISH · 2019 to 2019
$3.0M
Cortical spatiotemporal plasticity in humansR01DC004855 · NIDCD · UNIVERSITY OF UTAH · PI NAGARAJAN, SRIKANTAN S. · 2002 to 2011
$2.9M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Neuroimaging of Speech Motor ControlR01DC010145 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS · 2010 to 2014
$1.8M
Imaging sensorimotor adaptation and compensation of speechR01DC013979 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS, NAGARAJAN, SRIKANTAN S. · 2014 to 2018
$1.7M
Multimodal modeling framework for fusing structural and functional connectome dataR01EB022717 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI NAGARAJAN, SRIKANTAN S., RAJ, ASHISH · 2016 to 2018
$1.6M
Howard Hughes Medical InstituteNIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS RF1 AG062196NIA NIH HHS U01 AG052943NIBIB NIH HHS R01 EB022717NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC004855NIDCD NIH HHS R01 DC010145NIDCD NIH HHS R01 DC013979NIDCD NIH HHS R01 DC017696NIMH NIH HHS P50 MH119569NIMH NIH HHS R01 MH068725NIMH NIH HHS R21 MH110208NINDS NIH HHS R01 NS050915NINDS NIH HHS R21 NS076171NINDS NIH HHS R56 NS050915
6 · The paper itself

Abstract

Schizophrenia is a neurocognitive illness characterized by behavioral and neural impairments in both early auditory processing and higher order verbal working memory. Previously we have shown intervention-specific cognitive performance improvements with computerized, targeted training of auditory processing (AT) when compared to a computer games (CG) control intervention that emphasized visual processing. To investigate spatiotemporal changes in patterns of neural activity specific to the AT intervention, the current study used magnetoencephalography (MEG) imaging to derive induced high gamma band oscillations (HGO) during auditory encoding, before and after 50 h (∼10 weeks) of exposure to either the AT or CG intervention. During stimulus encoding, AT intervention-specific changes in high gamma activity occurred in left middle frontal and left middle-superior temporal cortices. In contrast, CG intervention-specific changes were observed in right medial frontal and supramarginal gyri during stimulus encoding, and in bilateral temporal cortices during response preparation. These data reveal that, in schizophrenia, intensive exposure to either training of auditory processing or exposure to visuospatial activities produces significant but complementary patterns of cortical function plasticity within a distributed fronto-temporal network. These results underscore the importance of delineating the specific neuroplastic effects of targeted behavioral interventions to ensure desired neurophysiological changes and avoid unintended consequences on neural system functioning.

Indexed as

AdultCognitive DysfunctionCognitive RemediationFemaleFrontal LobeGamma RhythmHumansMagnetoencephalographyMaleMemory, Short-TermNeuronal PlasticitySchizophreniaSpeech PerceptionTemporal LobeCognitive trainingLinguistic processingMagnetoencephalographyNeuroplasticity

Identifiers

PMID31648842
PMCPMC7035971
OpenAlexW2981511482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.