Evidence map›Paper›PMID 31648696›Full record

ArticleKidney international2019

"Permissive AKI" with treatment of heart failure.

Chirag R Parikh, Steven G Coca

Abstract readComment
PubMed Publisher
In one paragraph

Article in Kidney international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Right Heart Function in Cardiorenal Syndrome.Current heart failure reports · 2022
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Taboo in cardiology: renin-angiotensin-aldosterone system antagonists worsening renal failure.European heart journal supplements : journal of the European Society of Cardiology · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. How to interpret serum creatinine increases during decongestion.Frontiers in cardiovascular medicine · 2022
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Chirag R ParikhDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: chirag.parikh@jhmi.edu.
Steven G CocaDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: Steven.Coca@mssm.edu.
Icahn School of Medicine at Mount Sinai · USJohns Hopkins University · US

Funding

Novel Biomarkers in Cardiac Surgery to Detect Acute Kidney InjuryR01HL085757 · NHLBI · YALE UNIVERSITY · PI PARIKH, CHIRAG R · 2007 to 2019
$10.3M
Novel serum and urinary biomarkers of diabetic kidney diseaseR01DK096549 · NIDDK · YALE UNIVERSITY · PI COCA, STEVEN G · 2012 to 2016
$2.9M
Impact of Exercise on Kidney Function and Injury among Elders in the LIFE TrialR01DK115562 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI COCA, STEVEN G, SHLIPAK, MICHAEL G · 2018 to 2020
$2.2M
Leveraging Clinical Trials of Diabetic Kidney Disease to Advance BiomarkersU01DK106962 · NIDDK · YALE UNIVERSITY · PI COCA, STEVEN G, PARIKH, CHIRAG R · 2015 to 2019
$1.3M
NHLBI NIH HHS R01 HL085757NIDDK NIH HHS R01 DK096549NIDDK NIH HHS R01 DK115562NIDDK NIH HHS U01 DK106962
6 · The paper itself

Abstract

Renin-angiotensin-aldosterone system inhibitors have proven clinical benefit in management of patients with heart failure with reduced ejection fraction. However, there are no guidelines to manage decline in kidney function that occurs with initiation and titration of renin-angiotensin-aldosterone system agents during management of heart failure. We discuss the complex interplay of kidney function and heart failure in the presence of renin-angiotensin-aldosterone system agents and suggest a clinical algorithm for management of acute decline in kidney function.

Indexed as

Acute Kidney InjuryHeart FailureEnalaprilGlomerular Filtration RateHumansMineralocorticoid Receptor AntagonistsRenin-Angiotensin SystemStroke VolumeEnalaprilMineralocorticoid Receptor Antagonists

Identifiers

PMID31648696
OpenAlexW2980981890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.