ArticleTurkish journal of medical sciences2019
Alterations in serum levels of copper, zinc, and selenium among children with sickle cell anemia
Article in Turkish journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Zinc level and its impact on the phenotype of sickle cell disease.Annals of hematology · 2025Trial
- Trace Elements in Different Blood Products Used in Neonatal Transfusion: Arsenic and Selenium.International journal of molecular sciences · 2025Article
- Thyroid function abnormalities in individuals with sickle cell disease: a meta-analysis.Thyroid research · 2025Review
- Abnormal erythrocyte-related parameters in children with Pb, Cr, Cu and Zn exposure.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Prevalence, Risk Factors, and Complications of Sickle Cell Disease in Saudi Arabia: A Systematic Review.Cureus · 2024Review
- Catalase, Glutathione Peroxidase, and Peroxiredoxin 2 in Erythrocyte Cytosol and Membrane in Hereditary Spherocytosis, Sickle Cell Disease, and β-Thalassemia.Antioxidants (Basel, Switzerland) · 2024Article
- Copper/Zinc Ratio in Childhood and Adolescence: A Review.Metabolites · 2023Review
- Zinc, Magnesium, and Copper Levels in Patients with Sickle Cell Disease: A Systematic Review and Meta-analysis.Avicenna journal of medicine · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/aim: Oxidative stress contributes to pathophysiological dysfunction in sickle cell anemia (SCA). Copper (Cu) is a prooxidant, whereas zinc (Zn) and selenium (Se) are antioxidant trace elements. This study investigates the serum levels of Cu, Zn, and Se among children with SCA. Materials and methods: This cross-sectional study was performed at King Khalid University Hospital, Riyadh. Thirty-three children with SCA in steady state and 33 age- and sex-matched normal healthy children were included in the study. Cu, Zn, and Se levels were measured by inductively coupled plasma-mass spectrometry (ICP-MS) instrument. Results: The median serum Cu levels among SCA patients (1.3 μg/mL) were higher than those of the controls (0.88 μg/mL; P < 0.0001). Zn (0.61 μg/mL) and Se (74 ng/mL) levels among SCA patients, however, were significantly lower than those of the controls (0.94 μg/mL; P < 0.0001) and (91.2 ng/mL; P < 0.0001), respectively. The Cu/Zn ratio among SCA patients (1.92) was higher than that of the controls (0.98). Conclusion: Decreased blood levels of antioxidant trace elements may contribute to the pathophysiology in SCA by promoting oxidative stress. The monitoring of trace element levels in SCA appears to be vital for decreasing morbidity associated with the disorder.
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