ReviewGigaScience2019
Key challenges facing data-driven multicellular systems biology.
Review in GigaScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Article
- New insights in metabolism modelling to decipher plant-microbe interactions.The New phytologist · 2025Review
- A Bioinformatics Investigation of Hub Genes Involved in Treg Migration and Its Synergistic Effects, Using Immune Checkpoint Inhibitors for Immunotherapies.International journal of molecular sciences · 2024Article
- Phenotype Control techniques for Boolean gene regulatory networks.Bulletin of mathematical biology · 2023Review
- Phenotype control techniques for Boolean gene regulatory networks.bioRxiv : the preprint server for biology · 2023Article
- Graph Visualization: Alternative Models Inspired by Bioinformatics.Sensors (Basel, Switzerland) · 2023Review
- Model certainty in cellular network-driven processes with missing data.PLoS computational biology · 2023Article
- A computational modeling approach for predicting multicell spheroid patterns based on signaling-induced differential adhesion.PLoS computational biology · 2022Article
- Seven challenges in the multiscale modeling of multicellular tissues.WIREs mechanisms of disease · 2022Review
- SupportingPRIMUS : problems, resources, and issues in mathematics undergraduate studies · 2022Article
- A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling.iScience · 2021Article
- Size scaling in collective cell growth.Development (Cambridge, England) · 2021Article
- Multiscale modeling in disease.Current opinion in systems biology · 2021Article
- Systems biology for crop improvement.The plant genome · 2021Review
- Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- High-throughput microscopy reveals the impact of multifactorial environmental perturbations on colorectal cancer cell growth.GigaScience · 2021Article
- A multiscale model via single-cell transcriptomics reveals robust patterning mechanisms during early mammalian embryo development.PLoS computational biology · 2021Article
- Review
- Multi-scale models of lung fibrosis.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- A Perspective on Expanding Our Understanding of Cancer Treatments by Integrating Approaches from the Biological and Physical Sciences.SLAS discovery : advancing life sciences R & D · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Increasingly sophisticated experiments, coupled with large-scale computational models, have the potential to systematically test biological hypotheses to drive our understanding of multicellular systems. In this short review, we explore key challenges that must be overcome to achieve robust, repeatable data-driven multicellular systems biology. If these challenges can be solved, we can grow beyond the current state of isolated tools and datasets to a community-driven ecosystem of interoperable data, software utilities, and computational modeling platforms. Progress is within our grasp, but it will take community (and financial) commitment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.