Evidence map›Paper›PMID 31648005›Full record

SynthesisExperimental gerontology2019

Brain activity during dual task gait and balance in aging and age-related neurodegenerative conditions: A systematic review.

Melike Kahya, Sanghee Moon, Maud Ranchet, Rachel R Vukas, Kelly E Lyons, Rajesh Pahwa, Abiodun Akinwuntan, Hannes Devos

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Experimental gerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 7 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 7 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Melike KahyaDepartment of Physical Therapy and Rehabilitation Science, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: mkahya@kumc.edu.
Sanghee MoonDepartment of Physical Therapy and Rehabilitation Science, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: smoon@kumc.edu.
Maud RanchetUniversity of Lyon, IFSTTAR, TS2 LESCOT, Lyon, France. Electronic address: maud.ranchet@ifsttar.fr.
Rachel R VukasA.R. Dykes Library of the Health Sciences, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: rvukas@kumc.edu.
Kelly E LyonsDepartment of Neurology, School of Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: klyons@kumc.edu.
Rajesh PahwaDepartment of Neurology, School of Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: rpahwa@kumc.edu.
Abiodun AkinwuntanDepartment of Physical Therapy and Rehabilitation Science, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, USA; Office of the Dean, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: aakinwuntan@kumc.edu.
Hannes DevosDepartment of Physical Therapy and Rehabilitation Science, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: hdevos@kumc.edu.
University of Kansas Medical Center · USUniversité Claude Bernard Lyon 1 · FR

Funding

University of Kansas Alzheimer's Disease Research Center (KU ADRC)P30AG072973 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jaime Perales Puchalt · 2021 to 2026
$25.3M
University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SWERDLOW, RUSSELL H. · 2011 to 2020
$16.6M
Kansas University Training Program in Neurological and Rehabilitation SciencesT32HD057850 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jacob J. Sosnoff · 2009 to 2026
$3.4M
Neurophysiological Changes in Pre-clinical Alzheimer's DiseaseK01AG058785 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DEVOS, HANNES · 2019 to 2023
$638k
NIA NIH HHS K01 AG058785NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG072973NICHD NIH HHS T32 HD057850
6 · The paper itself

Abstract

The aims of this systematic review were to investigate (1) real-time brain activity during DT gait and balance, (2) whether changes in brain activity correlate with changes in behavioral outcomes in older adults and people with age-related neurodegenerative conditions. PubMed, PsycINFO, and Web of Science were searched from 2009 to 2019 using the keywords dual task, brain activity, gait, balance, aging, neurodegeneration, and other related search terms. A total of 15 articles were included in this review. Functional near-infrared spectroscopy and electroencephalogram measures demonstrated that older adults had higher brain activity, particularly in the prefrontal cortex (PFC), compared to young adults during dual task gait and balance. Similar neurophysiological results were observed in people with age-related neurodegenerative conditions. Few studies demonstrated a relationship between increased brain activity and better behavioral outcomes. This systematic review supports the notion that aging and age-related neurodegenerative conditions are associated with neuronal network changes, resulting in increased brain activity specifically in the PFC. Further studies are warranted to assess the relationship between increased PFC activation during dual task gait and balance and behavioral outcomes to better optimize the rehabilitation interventions.

Indexed as

AgingElectroencephalographyGaitHumansNeurodegenerative DiseasesPostural BalancePrefrontal CortexSpectroscopy, Near-InfraredBalanceBrain activityDual taskEEGfNIRSGaitNeurodegenerationOlder adults

Identifiers

PMID31648005
PMCPMC6876748
OpenAlexW2981968650

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.