Evidence map›Paper›PMID 31647997›Full record

ReviewGene2020

TAZ encodes tafazzin, a transacylase essential for cardiolipin formation and central to the etiology of Barth syndrome.

Anders O Garlid, Calvin T Schaffer, Jaewoo Kim, Hirsh Bhatt, Vladimir Guevara-Gonzalez, Peipei Ping

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Barth Syndrome:Genes · 2025
    Review
  5. Article
  6. What can ATP content tell us about Barth syndrome muscle phenotypes?Journal of translational genetics and genomics · 2025
    Article
  7. Article
  8. Dilated Cardiomyopathy: A Genetic Journey from Past to Future.International journal of molecular sciences · 2024
    Review
  9. A Barth Syndrome Patient-DerivedInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Phospholipids: Identification and Implication in Muscle Pathophysiology.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anders O GarlidCardiovascular Data Science Training Program at UCLA, University of California at Los Angeles, CA 90095, USA; Department of Physiology, University of California at Los Angeles, CA 90095, USA. Electronic address: aogarlid@g.ucla.edu.
Calvin T SchafferCardiovascular Data Science Training Program at UCLA, University of California at Los Angeles, CA 90095, USA; Department of Physiology, University of California at Los Angeles, CA 90095, USA.
Jaewoo KimCardiovascular Data Science Training Program at UCLA, University of California at Los Angeles, CA 90095, USA; Department of Physiology, University of California at Los Angeles, CA 90095, USA.
Hirsh BhattCardiovascular Data Science Training Program at UCLA, University of California at Los Angeles, CA 90095, USA; Department of Physiology, University of California at Los Angeles, CA 90095, USA.
Vladimir Guevara-GonzalezCardiovascular Data Science Training Program at UCLA, University of California at Los Angeles, CA 90095, USA; Department of Mathematics, University of California at Los Angeles, CA 90095, USA.
Peipei PingCardiovascular Data Science Training Program at UCLA, University of California at Los Angeles, CA 90095, USA; Department of Physiology, University of California at Los Angeles, CA 90095, USA; Department of Medicine/Cardiology, University of California at Los Angeles, CA 90095, USA; Department of Bioinformatics, University of California at Los Angeles, CA 90095, USA; Scalable Analytics Institute (ScAi), University of California at Los Angeles, CA 90095, USA. Electronic address: ppingucla@gmail.com.
University of California, Los Angeles · US

Funding

TRAININGU54GM114833 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LINDSEY, MERRY L., PING, PEIPEI · 2014 to 2017
$13.8M
Omics Phenotyping for Identifying Molecular Signatures of the Healthy and Failing Heart: An Integrated Data Science PlatformR35HL135772 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI · 2017 to 2023
$6.4M
The Gene Wiki: Community intelligence applied to gene annotationR01GM089820 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SU, ANDREW I · 2010 to 2021
$5.2M
Medical Imaging Informatics Training GrantT32EB016640 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALEX BUI, William Hsu · 2013 to 2026
$2.3M
NHLBI NIH HHS R35 HL135772NIBIB NIH HHS T32 EB016640NIGMS NIH HHS R01 GM089820NIGMS NIH HHS U54 GM114833
6 · The paper itself

Abstract

Tafazzin, which is encoded by the TAZ gene, catalyzes transacylation to form mature cardiolipin and shows preference for the transfer of a linoleic acid (LA) group from phosphatidylcholine (PC) to monolysocardiolipin (MLCL) with influence from mitochondrial membrane curvature. The protein contains domains and motifs involved in targeting, anchoring, and an active site for transacylase activity. Tafazzin activity affects many aspects of mitochondrial structure and function, including that of the electron transport chain, fission-fusion, as well as apoptotic signaling. TAZ mutations are implicated in Barth syndrome, an underdiagnosed and devastating disease that primarily affects male pediatric patients with a broad spectrum of disease pathologies that impact the cardiovascular, neuromuscular, metabolic, and hematologic systems.

Indexed as

AcyltransferasesAnimalsApoptosisBarth SyndromeCardiolipinsHumansMitochondriaSignal TransductionTranscription FactorsAcyltransferasesCardiolipinsTranscription FactorsApoptosisClinical case reportsMitochondrial biologyRare mitochondrial diseases

Identifiers

PMID31647997
PMCPMC7646589
OpenAlexW2982271230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.