ArticlePloS one2019
Acute sprint exercise transcriptome in human skeletal muscle.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- PERM1-An Emerging Transcriptional Regulator of Mitochondrial Biogenesis: A Systematic Review.Genes · 2024Pooled it
- Effects of including sprints during prolonged cycling on hormonal and muscular responses and recovery in elite cyclists.Scandinavian journal of medicine & science in sports · 2021Trial
- MAFF is a transcription factor that regulates contraction-induced skeletal muscle transcription.Life science alliance · 2026Article
- Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats.Nature communications · 2026Article
- Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium.bioRxiv : the preprint server for biology · 2026Article
- The central benefit of physiologically induced ketogenic states.The Journal of physiology · 2026Review
- Lavender Essential Oil-Induced Enhancement of Exercise-Responsive Myokine Expression and Alteration of Muscle-Related Gene Networks in an in Vitro Muscle Contraction Model.International journal of molecular sciences · 2026Article
- Intermittent AP-1 activation in muscles contributes to exercise-induced health benefits.bioRxiv : the preprint server for biology · 2026Article
- Does High-Intensity Interval Training Increase Muscle Strength, Muscle Mass, and Muscle Endurance? A Systematic Review and Meta-Analysis.Sports (Basel, Switzerland) · 2025Review
- Transcriptomic time course of skeletal muscle disuse and rehabilitation in middle-aged adults.Physiological reports · 2025Article
- Multi-Omics Identification ofBiology · 2025Article
- The universal role of adaptive transcription in health and disease.The FEBS journal · 2025Review
- NOR-1 Overexpression Elevates Myoglobin Expression via PERM1 and Enhances Mitochondrial Function and Endurance in Skeletal Muscles of Aged Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Role of theGenes · 2024Review
- Molecular aspects of the exercise response and training adaptation in skeletal muscle.Free radical biology & medicine · 2024Review
- Decreased mitochondrial-related gene expression in adipose tissue after acute sprint exercise in humans: A pilot study.Physiological reports · 2024Article
- High expression of transcription factor EGR1 is associated with postoperative muscle atrophy in patients with knee osteoarthritis undergoing total knee arthroplasty.Journal of orthopaedic surgery and research · 2024Article
- Impact of exercise and fasting on mitochondrial regulators in human muscle.Translational exercise biomedicine · 2024Article
- Molecular profiling of high-level athlete skeletal muscle after acute endurance or resistance exercise - A systems biology approach.Molecular metabolism · 2024Article
- Acute Effects of Single Versus Combined Inhaled β2-Agonists Salbutamol and Formoterol on Time Trial Performance, Lung Function, Metabolic and Endocrine Variables.Sports medicine - open · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine global gene expression response to profound metabolic and hormonal stress induced by acute sprint exercise.
methodsHealthy men and women (n = 14) performed three all-out cycle sprints interspersed by 20 min recovery. Muscle biopsies were obtained before the first, and 2h and 20 min after last sprint. Microarray analysis was performed to analyse acute gene expression response and repeated blood samples were obtained.
resultsIn skeletal muscle, a set of immediate early genes, FOS, NR4A3, MAFF, EGR1, JUNB were markedly upregulated after sprint exercise. Gene ontology analysis from 879 differentially expressed genes revealed predicted activation of various upstream regulators and downstream biofunctions. Gene signatures predicted an enhanced turnover of skeletal muscle mass after sprint exercise and some novel induced genes such as WNT9A, FZD7 and KLHL40 were presented. A substantial increase in circulating free fatty acids (FFA) was noted after sprint exercise, in parallel with upregulation of PGC-1A and the downstream gene PERM1 and gene signatures predicting enhanced lipid turnover. Increase in growth hormone and insulin in blood were related to changes in gene expressions and both hormones were predicted as upstream regulators.
conclusionThis is the first study reporting global gene expression in skeletal muscle in response to acute sprint exercise and several novel findings are presented. First, in line with that muscle hypertrophy is not a typical finding after a period of sprint training, both hypertrophy and atrophy factors were regulated. Second, systemic FFA and hormonal and exposure might be involved in the sprint exercise-induced changes in gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.