ArticleMolecular biology and evolution2020
Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss.
Article in Molecular biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 67 citations in OpenAlex.
- Trypanosomal MICOS Is Assembled on Non-Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins.Molecular microbiology · 2026Article
- Phylogenetic ancestry of Metamonada proteins points to a common origin of mitochondria in all eukaryotes.Molecular biology and evolution · 2026Article
- Magnetotaxis in an anaerobic ciliate via tripartite syntrophy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Variations in methane emissions from dairy cows: associations with rumen microbial synergy and metabolic pathway divergence.Journal of animal science and biotechnology · 2026Article
- Capturing the extensive diversity of marine anaerobic scuticociliates (Oligohymenophorea, Ciliophora) through cultivation.Marine life science & technology · 2026Article
- Single-cell transcriptomics reveals lateral transfers of multiple functional genes from prokaryotes to free-living ciliated protists in detrital food webs.Marine life science & technology · 2026Article
- Evolutionary assembly of a unique purple-green photosymbiosis revealed by expanded ciliate diversity.The ISME journal · 2026Article
- Distinct evolutionary origins and mixed-mode transmissions of methanogenic endosymbionts are revealed in anaerobic ciliated protists.Marine life science & technology · 2025Article
- Bioenergetics evolution: the link between Earth's and Life's history.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Article
- Novel findings on the mitochondria in ciliates, with description of mitochondrial genomes of six representatives.Marine life science & technology · 2025Article
- Article
- Transcriptome and Evolutionary Analysis of Pseudotrichomonas keilini, a Free-Living Anaerobic Eukaryote.Genome biology and evolution · 2024Article
- Diverse signatures of convergent evolution in cactus-associated yeasts.PLoS biology · 2024Article
- Horizontal gene transfer in eukaryotes: aligning theory with data.Nature reviews. Genetics · 2024Review
- Methanogenic symbionts of anaerobic ciliates are host and habitat specific.The ISME journal · 2024Article
- Genomic Basis of Freshwater Adaptation in the Palaemonid Prawn Genus Macrobrachium: Convergent Evolution Following Multiple Independent Colonization Events.Journal of molecular evolution · 2023Article
- The energy metabolism of Balantidium polyvacuolum inhabiting the hindgut of Xenocypris davidi.BMC genomics · 2023Article
- Diverse signatures of convergent evolution in cacti-associated yeasts.bioRxiv : the preprint server for biology · 2023Article
- Mitochondrial metabolism of the facultative parasite Chilodonella uncinata (Alveolata, Ciliophora).Parasites & vectors · 2023Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes.
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