ArticleAmerican journal of epidemiology2020
Additive and Multiplicative Interactions Between Genetic Risk Score and Family History and Lifestyle in Relation to Risk of Type 2 Diabetes.
Article in American journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Genetic risk of type 2 diabetes modifies the association between lifestyle and glycemic health at 5 years postpartum among high-risk women.BMJ open diabetes research & care · 2024Trial
- Epigenetic and genetic factors modifying the association between diet quality and incident type 2 diabetes: the EPIC-Potsdam cohort.Cardiovascular diabetology · 2026Article
- Prevalence and determinants of chronic non-communicable diseases among prison inmates in the city of Tete, Mozambique: a cross-sectional study.BMC public health · 2025Article
- Outdoor light spending time, genetic predisposition and incident Parkinson's disease: the mediating effect of lifestyle and vitamin D.Journal of health, population, and nutrition · 2025Article
- Association of spontaneous abortion and lifestyle with diabetes mellitus in women: a cross-sectional study in UK Biobank.BMC pregnancy and childbirth · 2025Article
- Machine learning reveals heterogeneous associations between environmental factors and cardiometabolic diseases across polygenic risk scores.Communications medicine · 2024Article
- Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank.Diabetes care · 2024Article
- Metabolic profiling of smoking, associations with type 2 diabetes and interaction with genetic susceptibility.European journal of epidemiology · 2024Article
- Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study.Journal of atherosclerosis and thrombosis · 2023Article
- Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case-control study.Biology of sex differences · 2023Article
- Interactions Between Genetic Risk and Diet Influencing Risk of Incident Female Gout: Discovery and Replication Analysis of Four Prospective Cohorts.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study.Scientific reports · 2023Article
- Ancestry: How researchers use it and what they mean by it.Frontiers in genetics · 2023Article
- Sex differences in predictive factors for onset of type 2 diabetes in Japanese individuals: A 15-year follow-up study.Journal of diabetes investigation · 2023Article
- Genetic risk score to improve prediction and treatment in gestational diabetes mellitus.Frontiers in endocrinology · 2022Review
- Genetic susceptibility, family history of diabetes and healthy lifestyle factors in relation to diabetes: A gene-environment interaction analysis in Chinese adults.Journal of diabetes investigation · 2021Article
- A Genetic Risk Score Improves the Prediction of Type 2 Diabetes Mellitus in Mexican Youths but Has Lower Predictive Utility Compared With Non-Genetic Factors.Frontiers in endocrinology · 2021Article
- RE: "ADDITIVE AND MULTIPLICATIVE INTERACTIONS BETWEEN GENETIC RISK SCORE AND FAMILY HISTORY AND LIFESTYLE IN RELATION TO RISK OF TYPE 2 DIABETES".American journal of epidemiology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
Abstract
We examined interactions between lifestyle factors and genetic risk of type 2 diabetes (T2D-GR), captured by genetic risk score (GRS) and family history (FH). Our initial study cohort included 20,524 European-ancestry participants, of whom 1,897 developed incident T2D, in the Nurses' Health Study (1984-2016), Nurses' Health Study II (1989-2016), and Health Professionals Follow-up Study (1986-2016). The analyses were replicated in 19,183 European-ancestry controls and 2,850 incident T2D cases in the Women's Genome Health Study (1992-2016). We defined 2 categories of T2D-GR: high GRS (upper one-third) with FH and low GRS or without FH. Compared with participants with the healthiest lifestyle and low T2D-GR, the relative risk of T2D for participants with the healthiest lifestyle and high T2D-GR was 2.24 (95% confidence interval (CI): 1.76, 2.86); for participants with the least healthy lifestyle and low T2D-GR, it was 4.05 (95% CI: 3.56, 4.62); and for participants with the least healthy lifestyle and high T2D-GR, it was 8.72 (95% CI: 7.46, 10.19). We found a significant departure from an additive risk difference model in both the initial and replication cohorts, suggesting that adherence to a healthy lifestyle could lead to greater absolute risk reduction among those with high T2D-GR. The public health implication is that a healthy lifestyle is important for diabetes prevention, especially for individuals with high GRS and FH of T2D.
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