Evidence map›Paper›PMID 31647403›Full record

ArticleThe Journal of general virology2019

A novel murine model of differentiation-mediated cytomegalovirus reactivation from latently infected bone marrow haematopoietic cells.

Xue-Feng Liu, Suchitra Swaminathan, Shixian Yan, Flora Engelmann, Darryl Adelaide Abbott, Luke Andrew VanOsdol, Taylor Heald-Sargent, Longhui Qiu, Qing Chen, Andre Iovane and 2 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Immune surveillance of cytomegalovirus in tissues.Cellular & molecular immunology · 2024
    Review
  5. Article
  6. Article
  7. Control of Cytokines in Latent Cytomegalovirus Infection.Pathogens (Basel, Switzerland) · 2020
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xue-Feng LiuComprehensive Transplant Center, Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Suchitra SwaminathanDepartment of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Shixian YanComprehensive Transplant Center, Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Flora EngelmannComprehensive Transplant Center, Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Darryl Adelaide AbbottDepartment of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Luke Andrew VanOsdolComprehensive Transplant Center, Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Taylor Heald-SargentDivision of Pediatric Infectious Diseases, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Longhui QiuComprehensive Transplant Center, Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Qing ChenDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Andre IovaneComprehensive Transplant Center, Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Zheng ZhangComprehensive Transplant Center, Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michael M AbecassisComprehensive Transplant Center, Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Northwestern University · US

Funding

Precision Cell Isolation and Analysis CoreP01AI112522 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABECASSIS, MICHAEL M · 2015 to 2019
$11.9M
Mechanisms of MCMV reactivation in immunodeficient transplant recipientsR01AI112911 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABECASSIS, MICHAEL M · 2014 to 2017
$1.7M
NIAID NIH HHS P01 AI112522NIAID NIH HHS R01 AI112911
6 · The paper itself

Abstract

CD34+ myeloid lineage progenitor cells are an important reservoir of latent human cytomegalovirus (HCMV), and differentiation to macrophages or dendritic cells (DCs) is known to cause reactivation of latent virus. Due to its species-specificity, murine models have been used to study mouse CMV (MCMV) latency and reactivation

Indexed as

Cell DifferentiationVirus ActivationVirus LatencyAnimalsBiomarkersBone Marrow CellsCells, CulturedCytomegalovirusCytomegalovirus InfectionsDisease Models, AnimalFemaleGranulocyte-Macrophage Colony-Stimulating FactorHematopoietic Stem CellsHost-Pathogen InteractionsInterleukin-4KineticsBiomarkersGranulocyte-Macrophage Colony-Stimulating FactorInterleukin-4hematopoietic cellslatencyMCMVreactivation

Identifiers

PMID31647403
PMCPMC7137770
OpenAlexW2982254083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.