Evidence map›Paper›PMID 31647314›Full record

ArticleAutism : the international journal of research and practice2020

Identifying prognostic markers in autism spectrum disorder using eye tracking.

Elizabeth C Bacon, Adrienne Moore, Quimby Lee, Cynthia Carter Barnes, Eric Courchesne, Karen Pierce

Open access · greenAbstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 6 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Eye Tracking as a Treatment Monitoring Tool for Autism: A Multilevel Meta-Analysis.Autism research : official journal of the International Society for Autism Research · 2025
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Overall prognosis of preschool autism spectrum disorder diagnoses.The Cochrane database of systematic reviews · 2022
    Pooled it
  5. Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta-analysis.Autism research : official journal of the International Society for Autism Research · 2022
    Pooled it
  6. Pooled it
  7. Feasibility of a Novel Eye Gaze Shift Task in Autism Assessment: A Pilot Study.Research on child and adolescent psychopathology · 2026
    Article
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  17. The impact of attention to social information on the development of socialization in childhood.Scandinavian journal of child and adolescent psychiatry and psychology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elizabeth C BaconUniversity of California San Diego, USA.ORCID 0000-0002-6123-0462
Adrienne MooreUniversity of California San Diego, USA.
Quimby LeeUniversity of California San Diego, USA.
Cynthia Carter BarnesUniversity of California San Diego, USA.
Eric CourchesneUniversity of California San Diego, USA.
Karen PierceUniversity of California San Diego, USA.
University of California San Diego · US

Funding

TARGETING GENETIC PATHWAYS FOR BRAIN OVERGROWTH IN AUTISM SPECTRUM DISORDERSP50MH081755 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COURCHESNE, ERIC · 2007 to 2013
$10.3M
Detection of ASD at the 1st birthday as standard of care: The Get SET Early ModelR01MH104446 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, KAREN L · 2014 to 2018
$6.0M
INVESTIGATON OF COGNITIVE DYSFUNCTION IN AUTISMR01MH036840 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COURCHESNE, ERIC · 1985 to 2011
$5.9M
1/2-Testing the impact of early screening on the long-term outcomes of children with ASDR01MH121595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, KAREN L · 2020 to 2023
$4.9M
Discovering Eye Tracking Biomarkers of ASD with Diagnostic and Prognostic PowerR01MH118879 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, KAREN L · 2019 to 2023
$3.7M
Studying the Biology and Behavior of Autism at 1-Year: The Well-Baby Check-Up AppR01MH080134 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, KAREN L · 2008 to 2017
$3.3M
Developmental Functional Genomics in ASD ToddlersR01MH110558 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COURCHESNE, ERIC, LEWIS, NATHAN ENOCH · 2016 to 2020
$3.0M
NIMH NIH HHS P50 MH081755NIMH NIH HHS R01 MH036840NIMH NIH HHS R01 MH080134NIMH NIH HHS R01 MH104446NIMH NIH HHS R01 MH110558NIMH NIH HHS R01 MH118879NIMH NIH HHS R01 MH121595
6 · The paper itself

Abstract

While many children with autism spectrum disorder are now detected at young ages given the rise in screening and general awareness, little is known regarding the prognosis of early detected children. The brain is shaped by experience-dependent mechanisms; thus, what a child pays attention to plays a pivotal role in shaping brain development. Eye tracking can provide an index of a child's visual attention and, as such, holds promise as a technology for revealing prognostic markers. In this, 49 children aged 1-3 years with autism spectrum disorder participated in an eye-tracking test, the GeoPref Test, that revealed preference for social versus nonsocial images. Next, children participated in a comprehensive test battery 5-9 years following the initial GeoPref Test. Statistical tests examined whether early age eye tracking predicted later school-age outcomes in symptom severity, social functioning, adaptive behavior, joint attention, and IQ. Results indicated that toddlers with higher preference for geometric images demonstrated greater symptom severity and fewer gaze shifts at school age. This relationship was not found in relation to IQ or adaptive behavior. Overall, the GeoPref Test holds promise as a symptom severity prognostic tool; further development of eye-tracking paradigms may enhance prognostic power and prove valuable in validating treatment progress.

Indexed as

Eye-Tracking TechnologyAutism Spectrum DisorderBiomarkersChild, PreschoolFemaleHumansInfantMalePrognosisBiomarkersautism spectrum disordersdevelopmentdiagnosisschool-age children

Identifiers

PMID31647314
PMCPMC7166165
OpenAlexW2982126741

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.