Evidence map›Paper›PMID 31647222›Full record

ArticleBioconjugate chemistry2019

Fluorescence Imaging of Peripheral Nerves by a Na

Junior Gonzales, Paula Demetrio de Souza Franca, Yan Jiang, Giacomo Pirovano, Susanne Kossatz, Navjot Guru, Dimitry Yarilin, Akello J Agwa, Christina I Schroeder, Snehal G Patel and 3 more

Open access · greenAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024
    Review
  5. Article
  6. Review
  7. Neurosurgical Intervention for Nerve and Muscle Biopsies.Diagnostics (Basel, Switzerland) · 2024
    Review
  8. NabioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Development and Validation of Nerve-Targeted Bacteriochlorin Sensors.Journal of the American Chemical Society · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Leveraging synthetic chlorins for bio-imaging applications.Chemical communications (Cambridge, England) · 2020
    Article
  17. Fluorescence labeling of a NaEJNMMI research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 3 countries.

Junior Gonzales
Paula Demetrio de Souza FrancaDepartment of Otorhinolaryngology and Head and Neck Surgery , Federal University of São Paulo , São Paulo , Brazil.
Yan JiangInstitute for Molecular Bioscience , The University of Queensland , St Lucia , Queensland 4072 , Australia.ORCID 0000-0001-5277-804X
Giacomo Pirovano
Susanne Kossatz
Navjot Guru
Dimitry Yarilin
Akello J AgwaInstitute for Molecular Bioscience , The University of Queensland , St Lucia , Queensland 4072 , Australia.
Christina I SchroederInstitute for Molecular Bioscience , The University of Queensland , St Lucia , Queensland 4072 , Australia.ORCID 0000-0002-6737-6374
Snehal G Patel
Ian Ganly
Glenn F KingInstitute for Molecular Bioscience , The University of Queensland , St Lucia , Queensland 4072 , Australia.ORCID 0000-0002-2308-2200
Memorial Sloan Kettering Cancer Center · USThe University of Queensland · AU

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
Rapid, quantitative and affordable point-of-care diagnostics for oral and oropharyngeal cancerR43CA228815 · NCI · SUMMIT BIOMEDICAL IMAGING, LLC · PI BRAND, CHRISTIAN, REINER, THOMAS · 2018 to 2018
$300k
Evaluation of PARP1 targeted imaging as screening tool for esophageal adenocarcinomaK99CA218875 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KOSSATZ, SUSANNE · 2018 to 2018
$106k
NCI NIH HHS K99 CA218875NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204441NCI NIH HHS R43 CA228815
6 · The paper itself

Abstract

Twenty million Americans suffer from peripheral nerve injury caused by trauma and medical disorders, resulting in a broad spectrum of potentially debilitating side effects. In one out of four cases, patients identify surgery as the root cause of their nerve injury. Particularly during tumor resections or after traumatic injuries, tissue distortion and poor visibility can challenge a surgeon's ability to precisely locate and preserve peripheral nerves. Intuitively, surgical outcomes would improve tremendously if nerves could be highlighted using an exogeneous contrast agent. In clinical practice, however, the current standard of care-visual examination and palpation-remains unchanged. To address this unmet clinical need, we explored the expression of voltage-gated sodium channel Na

Indexed as

FluorescenceAnimalsCystine-Knot MiniproteinsFemaleHumansMiceMice, NudeMolecular ImagingNAV1.7 Voltage-Gated Sodium ChannelPeptide FragmentsPeripheral NervesCystine-Knot MiniproteinsNAV1.7 Voltage-Gated Sodium ChannelPeptide FragmentsSCN9A protein, humanScn9a protein, mouse

Identifiers

PMID31647222
PMCPMC7372312
OpenAlexW2981563419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.