ArticleBrain and behavior2019
Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Target-Specific Effects of Deep Brain Stimulation for Tourette Syndrome: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Function-Specific Localization in the Supplementary Motor Area: A Potential Effective Target for Tourette Syndrome.CNS neuroscience & therapeutics · 2025Trial
- Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024Article
- Tourette syndrome: clinical features, pathophysiology, and treatment.The Lancet. Neurology · 2023Review
- Mechanism of Tianma Gouteng Decoction in the treatment of Parkinson's disease based on network pharmacology and molecular docking.American journal of translational research · 2023Article
- Review
- Deep brain-machine interfaces: sensing and modulating the human deep brain.National science review · 2022Review
- Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review.Brain sciences · 2021Review
- Article
- Effects of Chemogenetic Inhibition of D1 or D2 Receptor-Containing Neurons of the Substantia Nigra and Striatum in Mice With Tourette Syndrome.Frontiers in molecular neuroscience · 2021Article
- Tourette syndrome research highlights from 2019.F1000Research · 2020Review
- Deep brain stimulation for Tourette's syndrome.Translational neurodegeneration · 2020Review
- Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome.Brain and behavior · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious studies found subthalamic nucleus deep brain stimulation (STN-DBS) has clinical effect on Parkinson's disease, dystonia, and obsessive compulsive disorder. It is noteworthy that only a few studies report the STN-DBS for Tourette's syndrome (TS). Globus pallidus interna (GPi)-DBS is the one of the most common targets for TS. So, this paper aims to investigate the neural oscillations in STN and GPi as well as the DBS effect between these two targets in same patients.
methodsThe local field potentials (LFPs) were simultaneously recorded from the bilateral GPi and STN in four patients with TS. The LFPs were decomposed into neural oscillations, and the frequency and time-frequency characteristics of the neural oscillations were analyzed across the conditions of resting, poststimulation, and movement.
resultsNo difference of resting LFP was found between the two targets. The poststimulation period spectral power revealed the high beta and gamma oscillations were recovered after GPi-DBS but remained attenuated after STN-DBS. The STN beta oscillation has fewer changes during tics than voluntary movement, and the gamma oscillation was elevated when the tics appeared.
conclusionThe high beta and gamma oscillations in GPi restored after GPi-DBS, but not STN-DBS. High beta and gamma oscillations may have physiological function in resisting tics in TS. The cortex compensation effect might be interfered by the STN-DBS due to the influence on the hyper-direct pathway but not GPi-DBS.
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